Pathology of the Nucleus

ISBN-13: 9783642746703 / Angielski / Miękka / 2011 / 343 str.

James C. E. Underwood; J. Crocker; P. Dalcin

Opis

New techniques make it possible for investigators to examine and sometimes quantify various aspects of nuclear morphology and function; now they can derive clinically and biologically useful information about the nucleus. This book draws together a series of techniques which have been successfully applied to the study of the nucleus of tumour cells. These are of fundamental importance to researchers in tumour histopathology and medical oncology. Detailed reviews are given of various aspects of the morphology, ploidy and karyotypic status and function of the nuclei in the cells of tumours and preneoplastic lesions. Topics covered include nuclear morphology in tumour diagnosis, the ultrastructure of the nucleus, karyotypic analyses of solid tumours, flow cytometric assessment of nuclear ploidy and other parameters, histomorphometry of the nucleus, and in situ hybridisation.

Spis treści

Nuclear Morphology and Grading in Tumours.- Ultrastructural Pathology of the Nucleus.- Nucleolar Organiser Regions.- Quantitation of the Nucleus.- Flow Cytometry in the Quantitation of DNA Aneuploidy and Cell Proliferation in Human Disease.- Karyotypic Analysis of Solid Tumors.- Techniques and Applications of In Situ Hybridisation.- Indexed in ISR.