Paraoxonases in Inflammation, Infection, and Toxicology

ISBN-13: 9781617796753 / Angielski / Miękka / 2012 / 212 str.

Srinivasa T. Reddy

Opis

Biomarkers are used in many aspects of health surveillance to identify disease pr- ence, track disease progression, monitor drug delivery or metabolism, or monitor chemical exposure. There is a recognized need to expand and improve biomarker identi?cation and quanti?cation. Exposures to the xenobiotic organophosphates (OPs) range from low-level, chronic exposure during pesticide application (e. g., on farms, in residences, or in the workplace) to high-dose, acute exposures incl- ing release of nerve agents or toxic industrial OPs. OPs can have both rapid and chronic toxicity, due to their action on speci?c esterases and lipases, most notably acetylcholinesterase (AChE) and neuropathic target esterase (NTE). In each of the above examples, a rapid and accurate assessment of the OP to which the person was exposed, degree of exposure, and time period of exposure will help direct therapy to the victim and assess the level of threat to others. Traditionally, metabolites for speci?c OPs can be measured in the urine after an exposure, such as 3,5,6-trichloro- 2-pyridinol for chlorpyrifos (CPS). However, there are several problems with this method. Usually, the metabolite is excreted for only a short period of several days after a signi?cant exposure. In addition, due to the widespread use of CPS and en- ronmental persistence of its breakdown products, the metabolites appear at a high background level in the general population (Hill et al. 1995). Their appearance does not indicate whether the individual was exposed to the harmful parent compound, or the harmless breakdown product.

Recenzje

From the reviews:

"This volume contains a selection of papers from the 3^rd International Conference on paraoxonases held at the University of California in Los Angeles ... . The paper quality and book construction is excellent, the print font size is ideal and, as would be expected, it contains a copious numbers of tables, graphs, schemes, chemical formulae, figures and photographs ... . The tome is rounded of with an adequate index of some 16 pages. This publication ... is a worthy and interesting addition." (S. C. Mitchell, ISSX Newsletter, May, 2011)

Spis treści

ApoE mimetic reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activity Geeta Datta, , Manjula Chaddha , Shaila P. Handattu, Mayakonda N. Palgunachari, Gaurav Nayyar, David W. Garber, Himanshu Gupta, C. Roger White and G.M. Anantharamaiah Interrelationships between paraoxonase-1 and monocyte chemoattractant protein-1 in the regulation of hepatic inflammation Jordi Camps, Judit Marsillach, Anna Rull, Carlos Alonso-Villaverde, and Jorge Joven Biomarkers of Sensitivity and Exposure in Washington State Pesticide Handlers JN Hofmann, MC Keifer, H Checkoway, AJ De Roos, FM Farin FM, RA Fenske, RJ Richter, G van Belle, CE Furlong Paraoxonase 1 (PON1) Status as a Risk Factor for Disease or Exposure Rebecca J Richter, Gail P Jarvik, Clement E Furlong Engineering Human PON1 in an E. coli Expression System. Stephanie M. Suzuki, Richard C. Stevens, Rebecca J. Richter, Toby B. Cole, Sarah Park, Tamara C. Otto, Douglas M. Cerasoli, David E. Lenz and Clement E. Furlong The Toxicity of Mixtures of Specific Organophosphorus (OP) Compounds is Modulated by Paraoxonase 1 (PON1) Status. Toby B. Cole, Karen Jansen, Sarah Park, Wan-Fen Li, Clement E. Furlong, and Lucio G. Costa Identification and Characterization of Biomarkers of Organophosphorus (OP) Exposures in Humans Jerry H. Kim, Richard C. Stevens, Michael J. MacCoss, David R. Goodlett, Alex Scherl, Rebecca J. Richter, Stephanie M. Suzuki, Clement E. Furlong Temporal and tissue-specific patterns of Pon3 expression in mouse: in situ hybridization analysis Diana M. Shih, Yu-Rong Xia, Janet M. Yu, and Aldons J. Lusis PON1 and Oxidative Stress in Human Sepsis and an Animal Model of Sepsis Dragomir Draganov, John Teiber, Catherine Watson, Charles Bisgaier, Jean Nemzek, Daniel Remeck, Theodore Standiford, Bert La DU Paraoxonase 1 attenuates human plaque atherogenicity: Relevance to the enzyme lactonase activity. Hagai Tavori, Jacob Vaya, Michael Aviram The role of Paraoxonase 1 in the detoxification of homocysteine thiolactone Hieronim Jakubowski Alteration of pon1 activity in adult and childhood obesity and its relation to adipokine levels Ildikó Seres, László Bajnok, Mariann Harangi, Ferenc Sztanek, Peter Koncsos, György Paragh Anti-inflammatory properties of paraoxonase-1 in atherosclerosis Bharti Mackness and Mike Mackness Paraoxonase1 (PON1) interactions with HDL, Antioxidants and macrophages regulate Atherogenesis – A protective role for HDL phospholipids Michal Efrat and Michael Aviram The effect of HDL mimetic peptide L-4F on PON1 Mohamad Navab, Susan Hama, Ladan Vakili, J. Brian Kim; Duc Tien, Shila Safarpoor, Nancy Ly, Ghazal Vakili, Greg Hough The contribution of high density lipoprotein apolipoproteins and derivatives to serum paraoxonase-1 activity and function. Richard W. James and Sara P. Deakin Paraoxonase 1, quorum sensing, and p. Aeruginosa infection: a novel model M.L. Estin, D.A. Stoltz And J. Zabner

Blurb

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