Paediatric Pathology

ISBN-13: 9781447130277 / Angielski / Miękka / 2011 / 942 str.

Colin Berry

Opis

Building on the success of the previous two editions with contributions from recognised experts in their fields this book is aimed at the general pathologist concerned with handling paediatric cases and autopsies. But the specialist paediatric pathologist will also find much of interest and value. Others working in germane specialties - such as obstetricians, neonatologists and paediatric surgeons - will also obtain much valuable information.
The third edition is updated in all respects and many new pathological entries are dealt with, including a chapter on diseases of bone marrow. The introduction of new genetic material is also evident throughout.

Recenzje

"...this volume represents a valuable resource in paediatric pathology and compares favourably with the others in the field." (Histopathology, on the 2nd ed.)

Spis treści

1 Examination of the Fetus and the Neonatal Autopsy.- History.- Dimensions.- Weights.- Dating.- Chronology of Early Pregnancy.- External Examination.- Internal Examination.- Abnormalities of Specific Systems.- Blighted Ova.- Normal Organ Weights in the Fetus.- Some Normal Historical Appearances During Development.- The Neonatal Autopsy.- Checklist for Paediatric Autopsy.- 2 Congenital Malformations.- Genetics of Common Malformations.- Chromosomal Abnormality and Malformations.- Human Teratogens.- Infectious Causes of Abnormal Development.- Paternal Effects of Teratogens.- 3 Cardiac Pathology.- Autopsy Technique.- Examination of the Arrangement of the Organs (Situs).- Sequential Segmental Analysis of the Heart.- Congenital Heart Disease.- Congenital Malformations of the Aorta.- Congenital Malformations of the Central Pulmonary Arteries.- Isolated Congenital Abnormalities of Endocardium, Myocardium and Pericardium.- Congenital Heart Block.- Complications of Congenital Heart Disease.- Syndromes Commonly Associated with Cardiovascular Malformations.- Cardiac Tumours.- 4 Central Nervous System.- Cell Populations in the CNS and their Reactions.- Assessment of Gestational Age.- Malformations.- Encephaloclastic Lesions.- Hypoxic-ischaemic Brain Damage.- Cerebral Palsy.- Hydrocephalus.- Raised Intracranial Pressure and Space-occupying Lesions.- Epilepsy.- Lead Poisoning.- Inherited Metabolic Disease.- Non-inherited Metabolic Encephalopathies.- Miscellaneous Neurodegenerative Conditions.- Neurocutaneous Syndromes.- Infections.- Demyelination.- Cerebrovascular Disease.- Trauma.- Sudden Infant Death Syndrome (SIDS).- Tumours.- 5 Gastrointestinal System.- Embryology.- Facial and Oral Abnormalities.- Salivary Glands.- Oesophagus.- Stomach.- Duodenum.- Pancreas.- Small Bowel.- Malformations of the Anus and Rectum.- Polypoid Lesions of the Large Bowel.- Ulcerative Colitis.- Crohn’s Disease.- Perforation of the Large Bowel.- Hernias.- Pneumatosis Intestinalis.- Malignant Tumours.- 6 Liver and Gallbladder.- Embryology.- Anomalies of Position, Form and Size.- Cystic Disease.- Erythroblastosis Fetalis.- Neonatal Jaundice.- Metabolic Defects Causing Unconjugated Hyperbilirubinaemia.- Inherited Metabolic Disease.- Giant Cell Transformation and Intrahepatic Cholestasis.- Obstructive Jaundice.- Intravenous Alimentation.- Infections.- Reye’s Syndrome.- Kwashiorkor.- Cirrhosis.- Thalassaemia.- Mucoviscidosis.- Nodular Regenerative Hyperplasia.- Budd-Chiari Syndrome.- Aflatoxicosis.- Tumours.- Gallbladder.- Cholecystitis.- Cholelithiasis.- 7 Respiratory System.- Development and Structure.- Nose and Nasopharynx.- Larnyx and Trachea.- Lungs.- Bronchial Lesions.- Lung Involvement in Metabolic Diseases.- Tumours.- 8 Kidney and Lower Urinary Tract.- Embryology.- Congenital Anomalies.- Cystic Diseases of the Kidney.- Renal Diseases Principally Affecting the Glomeruli.- Renal Vascular Disease.- Renal Infection.- Urolithiasis.- Hereditary Abnormalities of Renal Tubular Transport.- Renal Tumours.- Embryology of the Renal Pelvis, Ureter, Bladder and Urethra.- Renal Pelvis and Ureter.- Bladder.- Urethra.- Disorders of Differentiation of the Genital Tract.- 9 Bones and Joints.- Normal Development of the Skeletal System.- Abnormal Development.- Skeletal Abnormalities Developed Later in Childhood or Adolescence.- Osteogenesis Imperfecta.- Hyperostosis (Osteosclerosis).- Inborn Errors of Metabolism.- Metabolic Disorders Related to Bones.- Endocrine Disorders and the Skeleton.- Skeletal Changes in Haematological Disorders.- Chronic Polyarthritis.- Infections of Bones and Joints.- Tumours and Tumour-like Conditions.- 10 Muscle and Peripheral Nerve.- Muscle Biopsy Techniques.- Histological Features of Neuromuscular Disease.- Classification of Neuromuscular Disorders.- Myopathic Disorders.- Inflammatory Myopathies.- Myasthenia Gravis.- Neurogenic Disorders.- Diseases of Peripheral Nerve.- Genetically Determined Neuropathies.- Acquired Neuropathies.- 11 Spleen, Lymph Nodes and Immunoreactive Tissues.- Embryogenesis and Development.- Fetal Immunoreactivity.- Immune Deficiency States.- Other Diseases of the Thymus.- Anatomical Abnormalities of the Spleen.- Effects of Splenectomy.- Cysts, Hamartomas and Heterotopias.- Storage Disorders.- Langerhans’ Cell Histiocytosis.- Malignant Lymphomas.- 12 Bone Marrow.- Development of Haemopoiesis and Bone Marrow.- Normal Bone Marrow.- Anaemia.- Granulocytopenia.- Thrombocytopenia.- Pancytopenia.- Myelodysplasia.- Myeloproliferative Disorders.- Acute Lymphoblastic Leukaemias.- Thrombocytosis.- Histiocytic Disorders.- Metastatic Bone Marrow Disease.- 13 Endocrine Pathology.- Adrenal Cortex.- Adrenal Medulla and Paraganglia.- Pancreatic Islets.- Multiple Endocrine Neoplasia Syndromes.- Parathyroid Glands.- Pituitary.- Thyroid.- Hormonal Effects of Gonadal Tumours.- Ectopic Hormone Syndromes Associated with Tumours.- 14 Infectious Diseases.- Infections in Newborn Infants and Fetuses.- Infections in Malnourished Children.- Mycobacterial Infections.- Bacterial Infections.- Viral Infections.- Mycoplasma and Ureaplasma Infections.- Fungal Infections.- Protozoal Infections.- Rickettsial Diseases.- Parasitic Disease.- 15 AIDS.- Diagnosis of HIV Infection in Infants.- Clinical Features.- Systematic Pathology.- Opportunistic Infections.- AIDS Associated Neoplasms.- AIDS in African Children.- 16 Metabolic Disorders: a Simplified Approach to Their Diagnosis.- Blood Film Examination.- Bone Marrow Examination.- Urine Examination.- Neuronal Storage Disease: Diagnosis by Rectal Biopsy.- Glycogen Storage Disease.- Other Tissues and Techniques.- 17 Embryonal Tumours.- Aetiology.- Retinoblastoma.- Neuroblastoma.- Medulloblastoma.- Nephroblastoma.- Rhabdomyosarcoma.- Hepatoblastoma.- Teratomas.- Second Malignant Neoplasms in Children Surviving Embryonic Tumours.- 18 Sudden Unexpected Infant Death.- Necropsy Investigations.- Necropsy Findings.