Osteoporosis in Older Persons: Pathophysiology and Therapeutic Approach

ISBN-13: 9781848829244 / Angielski / Miękka / 2009 / 186 str.

Gustavo Duque

Opis

Although osteoporosis has been de? ned as a metabolic bone disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to enhanced bone fragility and a consequent increase in fracture risk, it is not clear that osteoporosis represents a single disease as much as a similar response of bone to different pathophysiologies. In the 1940s Fuller Albright and colleagues recognized osteoporosis of old age and distinguished it from osteoporosis associated with the postme- pausal state, as well as from osteoporosis from disuse, osteoporosis from malnutrition, and other forms of osteoporosis. He nevertheless pointed out that it was unclear how much of osteoporosis is due to old age per se, in view of the fact that in many cases osteoporosis of disuse, of malnutrition, of the postmenopausal state and of senility are inseparably superimposed. In this volume, Duque and Kiel have gathered an international panel of experts to highlight the unique features of senile osteoporosis and cons- eration of this disease spans the very basic through the clinical and the epidemiologic. As an organ which harbors stem cells, bone may clearly in? uence not only its own regeneration but also the regeneration of other tissues, notably the hematopoietic system."

Recenzje

From the reviews:

"The authors of this multiauthored book bring together new information on the molecular biology of bone physiology in this examination of osteoporosis in older persons. ... The intended audience includes all health practitioners who treat older patients with osteoporosis. Research scientists in the area will find this book useful as well. ... This book's demonstration of the complex relationship of bone health to adipose tissue and several powerful hormones will stimulate new thinking in the area of osteoporosis." (David O. Staats, Doody's Review Service, August, 2008)

"This is a simply outstanding compilation that provides a clear and concise review of the effect age has on the skeleton at the molecular/genetic level, in animal models as well as humans. ... It provides clinicians with an overview of cellular mechanisms leading to bone loss and researchers with insight into the clinical consequences of age-related skeletal change in older adults. That such a text has not previously been written and become a reference standard among clinicians, geriatricians, and researchers ... ." (Neil Binkley, JAMA, Vol. 300 (11), September, 2008)

Spis treści

Biology of Bone.- Aging and Bone.- Calciotropic Hormones.- Sex Steroids and Aging Bone.- Animal Models for Senile Osteoporosis.- Senile Osteoporosis as a Geriatric Syndrome.- Genetics of Osteoporosis in Older Age.- Fracture Epidemiology Among Individuals 75+.- Falls as a Geriatric Syndrome: How to Prevent Them? How to Treat Them?.- Non-Pharmacological Treatments for Falls and Fractures.- Medical Treatment of Age-Related Osteoporosis: Present and Future.- Treatment of Osteoporosis in Long-Term Care.- Fracture Care in the Elderly.

Blurb

Osteoporosis in Older Persons - Pathophysiology and Therapeutic Approach has the most up-to-date information about the pathophysiology and new therapeutic alternatives.

Until recently most effort concerning osteoporosis research was directed mainly at the mechanisms of a type of osteoporosis known as post-menopausal osteoporosis. It was only just recently that a new syndrome, osteoporosis in older persons, was recognized as a new entity with its own pathophysiology and potential treatments.
 
Highlights of this book include:-
 
- Many illustrations showing the basic biological pathways involved in bone aging, as well as the potential links between aging and the changes in bone biology
- Figures showing the potential therapeutic targets in bone to prevent and treat osteoporosis, complemented by a complete review on the current treatments
- Descriptions of the epidemiology of osteoporotic fractures and their impact on health care costs
- Coverage of fractures and their relationship with falls, including new invasive and non-invasive therapeutic approach for osteoporotic fractures
- A complete review of future treatments is included explaining their biological basis as well as their potential indications
 
Written by leading clinicians and practitioners in the field this book will be of use to those involved with aging bone research, geriatricians, gerontologists, and bone biologists, as well as offering medical trainees an understanding of the mechanisms of osteoporosis in the older person, with a practical approach to diagnosis and treatment in mind.