Oral Lipid-Based Formulations: Enhancing the Bioavailability of Poorly Water-Soluble Drugs

ISBN-13: 9780824729455 / Angielski / Twarda / 2007 / 368 str.

Hauss J. Hauss; David J. Hauss; David J. Hauss

Opis

Increasing knowledge of oral lipid-based formulations has shown their utility for aiding gastrointestinal absorption and reducing or eliminating the effect of food on the absorption of poorly soluble, lipophilic drugs. Despite its promise for addressing the persistent and growing problems surrounding the oral delivery of numerous poorly water-soluble drug candidates, industry has been slow to apply and further develop this technology. This title provides a comprehensive summary of the theoretical and practical aspects of oral lipid-based formulations for use in industry and to give greater understanding to a developing technology expected to assume more prominence in years to come.

Spis treści

Currently Marketed Oral Lipid-Based Dosage Forms: Drug Products and Excipients. Lipid-Based Excipients for Oral Drug Delivery. Feasibility Assessment for Scaling Initial Prototype Lipid-Based Formulations to Initial Phase I/II Clinical Trial Batches. Materials, Process and Manufacturing Considerations for Lipid-Based Hard Capsule Formats. Liquid Self-Micro-Emulsifying Drug Delivery Systems (SMEDDS). Lipid-Based Isotropic Solutions: Design Considerations. Lipid-Based Self-emulsifying Solid Dispersions. Using Preclinical Data to Dictate Formulation Strategies for Poorly Water-Soluble Drugs. Physiological Processes Governing the Gastrointestinal Absorption of Lipids and Lipophilic Xenobiotics. Characterizing Release from Lipid-Based Formulations. Using In Vitro Dynamic Lipolysis Modeling as a Tool for Exploring IVIVC Relationships for Oral Lipid-Based Formulations. Case Study: Rational Development of Self-Emulsifying Formulations for Improving the Oral Bioavailability of Poorly Soluble, Lipophilic Drugs. Design and Development of Supersaturatable SEDDS (S-SEDDS) Formulations for Enhancing the Gastrointestinal Absorption of Poorly Soluble Drugs

O autorze

David J. Hauss