Nutraceuticals in Veterinary Medicine

ISBN-13: 9783030046231 / Angielski / Twarda / 2019 / 1456 str.

Ramesh C. Gupta; Ajay Srivastava; Rajiv Lall

Recenzje

"The book is intended to serve academic, industry, and government sectors alike. It is appropriate for veterinarians at all levels of practice, but it will most commonly be used by general practice veterinarians. ... This book makes a great deal of information readily available in one place. It is appealing that it covers everything from the basics of specific nutraceuticals to their testing and regulation. It is nice to have a thorough database at your fingertips." (Jason B. Pieper, Doody's Book Reviews, November 08, 2019)

Spis treści

PRELIMINARY _03_2018

Introduction

Ramesh C. Gupta, Murray State University, Hopkinsville, KY, USA; and  

Ajay Srivastava and Rajiv Lall, Vets Plus Inc, Menomonie, WI, USA

Email: rgupta@murraystate.edu; drajay@vets-plus.com; lallr@vets-plus.com

 

I. COMMON NUTRACEUTICALS 

1. Curcumin/Turmeric

Naresh Chand, National Institutes of Health, Bathesda, MD, USA

Email: nchand@mail.nih.gov

And

Sally Frautschy, University of California Los Angeles, Los Angeles, CA, USA

Email: sfrautschy@mednet.ucla.edu

2. Fenugreek

Dinesh Kumar, W. Ramdas Singh, Anu Rahal, and Jitendra K. Malik

Indian Veterinary Research Institute, Izatnagar, Bareilly, India

      Email: dineshks17@gmail.com

3. Ashwagandha

Vijay K. Bharti, Jitendra K. Malik, and Ramesh C. Gupta 

Defense Institute of High Altitude Research (DIHAR), DRDO, Leh, India

Email: vijaykbharti@rediffmail.com

4. Shilajit

Shailesh K. Bhavsar*, Aswim M. Thaker, and Jitendra K. Malik

Anand Agricultural University, Anand, India

Email: skbhavsar@yahoo.com

5. Seabuckthorne and Apricot

Vijay K. Bharti

       Defense Institute of High Altitude Research (DIHAR), DRDO, Leh, India

       Email: vijaykbharti@rediffmail.com

6. Ginger

Shyam S. Sharma and K. Srinivasan, Dept. Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar, Mohali, India

Email: sssharma@niper.ac.in

7. Neem extract

Jitendra K. Malik, Former Joint Director (Research), and Head of the Division    

 of Pharmacology and Toxicology, Indian Veterinary Research Institute,  

 Bareilly, Dehradun, Uttarakhand, India

 Email: jkmalik48@gmail.com

8. Omega fatty acids

Szabina A. Stice, Division of Biotechnology and GRAS Notice Review, FDA, College Park, MD, USA

E-mail: szabina.stice@fda.hhs.gov

9. L-Tryptophan and 5-HTP

Ajay Srivastava, Vets Plus Inc, Menomonie, WI, USA

Email: drajay@vets-plus.com

10. Berberine

Ramesh C. Gupta, Murray State University, Hopkinsville, KY, USA

Email: rgupta@murraystate.edu

11. Glucosinolates and organosulfur compounds

Karyn Bischoff, Cornell University, Ithaca, NY, USA

Email: klb72@cornell.edu

12. Nutraceutical values of red mold rice for anti-diabetic and anticlastogenic   properties

Jacob A. C. Sanchez, Pampanga State Agricultural University, Pampanga, Philippines

Email: jacobsanchezph1@gmail.edu

13. Medium Chain Triglycerides

Yet to be assigned

 Email: 

14. Colostrum and Immunoglobulins 

 Dan Duberdieu, Vets Plus Inc, Menomonie, WI, USA

 Email: dand@vets-plus.com

15. Herbal Marijuana/Cannabis sativa

Joshua A. Hartsel, Delta-9 Technologies, LLC, Lake Forest, CA, USA

Email: jhartsel@gmail.edu

      

16. Juniper

 Rajinder Raina, Pawan K. Verma, Jitendra K. Malik, and Ramesh C. Gupta 

 Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu,       

 Jammu, India

 Email:  drrajinderraina@ymail.com

17. Natural preservatives and food additives

Ajay Srivastava and Tapan Gor, Vets Plus Inc, Menomonie, WI, USA

Email: drajay@vets-plus.com

18. Antioxidants in animal health 

Yogendra K. Gupta, All India Institute of Medical sciences. New Delhi, India

Email: ykgykg@gmail.com  or ykg@hotmail.com 

  

19. Polyphenols and flavonoids

       Satish K. Garg, Soumen Choudhury and Amit Shukla

       U.P. Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan    

        Vishwavidyalaya Evam Go-Anusandhan Sansthan (DUVASU), Mathura, India    

       Email: profsatish@gmail.com

        

II. PREBIOTICS, PROBIOTICS, SYNBIOTICS, AND ANTIMICROBIALS

20. Prebiotics and probiotics in feed and animal health

      Arturo Anadon, Universidad Complutense de Madrid, Madrid, Spain

       Email: anadon@vet.ucm.es

21. Synbiotics in animals health

      Jitendra K. Malik and Ramesh C. Gupta

       Former Joint Director (Research), and Head of the Division of     

       Pharmacology and Toxicology, Indian Veterinary Research Institute, Bareilly, 

       Dehradun, Uttarakhand, India

       Email: jkmalik48@gmail.com

22. Enzymes in feed and animal health

       Arturo Anadon, Universidad Complutense de Madrid, Madrid, Spain

       Email: anadon@vet.ucm.es

23. Optimization of mineral supplements for maximized animal productivity

Jeffery O. Hall, Utah State University, Logan, UT, USA

Email: jeffery.hall@usu.edu

24. Nutraceuticals used as antibacterial alternatives in animal health

      Arturo Anadon, Universidad Complutense de Madrid, Madrid, Spain

       Email: anadon@vet.ucm.es

25. Feed additives in animal health

Prafull Kumar and M.J. Saxena, Ayurvet, Ghaziabad, UP, India

Email:  pverma@ayurvet.com; mjsaxena@ayurvet.com

III. NUTRACEUTICALS IN ORGAN/SYSTEM DISORDERS

26. Nutraceuticals in arthritis

Ramesh C. Gupta, Murray State University, Hopkinsville, KY, USA

E-mail: rgupta@murraystate.edu

27. Nutraceuticals in oral health and periodontal diseases

 Yet to be assigned

        Email: 

28. Nutraceuticals in gastrointestinal conditions

Jamil Talukder, Vets Plus Inc, Menomonie, WI, USA

Email: jamilt@vets-plus.com

29. Nutraceuticals in hepatic and pancreatic diseases

Sharon Gwaltney-Brant, University of Illinois, Urbana-Champaign, IL, USA

Email: sharon.brant@mchsi.com

30. Nutraceuticals in genitourinary diseases

Robert W. Coppock, Toxicologist and Assoc Ltd, Vegreville, AB, Canada, USA

Email: r.coppock@toxicologist.ca

31. Nutraceuticals in cardiovascular diseases

Csaba Zoltani, Emeritus US Army Research Lab, Aberdeen Proving Ground, MD, USA

Email: c.zoltani@gmail.com

32. Nutraceuticals in respiratory diseases

Ajay Srivastava, Vets Plus Inc, Menomonie, WI, USA

Email: drajay@vets-plus.com

33. Nutraceuticals in reproductive disorders

Moges Woldemeskel, College of Veterinary Medicine, University of Georgia, GA, USA

Email: mwoldem@uga.edu

34. Nutraceuticals in dermatological disorders

Moges Woldemeskel, College of Veterinary Medicine, University of Georgia, GA, USA

Email: mwoldem@uga.edu

35. Nutraceuticals in mastitis

 Robert W. Coppock, Toxicologist and Assoc Ltd, Vegreville, AB, Canada, USA

 Email: r.coppock@toxicologist.ca

36. Nutraceuticals in immune disorders

Moges Woldemeskel, College of Veterinary Medicine, University of Georgia, GA, USA

Email: mwoldem@uga.edu

37. Nutraceuticals for wound healing

Ajay Srivastava, Vets Plus Inc, Menomonie, WI, USA

Email: drajay@vets-plus.com

38. Nutraceuticals for calming and stress

 Yet to be assigned

 Email:

39. Nutraceuticals for cognitive dysfunction

Ramesh C. Gupta, Murray State University, Hopkinsville, KY, USA

Email: rgupta@murraystate.edu

40. Nutraceuticals for antiaging

Yet to be assigned

 Email:

41. Nutraceuticals in cancer prevention and cure

 Subhash C. Gupta, Banaras Hindu University, Banaras, UP, India

Email: subhashg167@gmail.com

42. Nutraceuticals alone or in combination with chemotherapeutic agents for prevention and treatment of cancer

M. Waheed Roomi, Dr Rath Research Institute, Santa Clara, CA, USA

Email: w.roomi@drrath.com

43. Nutraceuticals in obesity and metabolic disorders

Rhian B. Cope, Health Product Regulation Group, Woden ACT, Australia

Email: rhian.Cope@health.gov.au

44. Nutraceuticals for ticks, fleas and other ectoparasites

Ramesh C. Gupta, Murray State University, Hopkinsville, KY, USA

Email: rgupta@murraystate.edu

45. Nutraceuticals in hunting, sporting and performance enhancing activities

Yet to be assigned

 Email:  

 

IV. NUTRACEUTICALS IN SPECIFIC ANIMAL SPECIES

46. Nutraceuticals in cattle health and diseases

Ayhan Filazi and Begum Yurdakok Dikmen, Ankara University, Ankara, Turkey

Email: afilazi@gmail.com

47. Nutraceuticals in equine health and diseases

Yet to be assigned

 Email:

48. Nutraceuticals in camelids

 Tarun K. Gahlot, Bikaner Veterinary Science University, 

  Bikaner, India

 Email: tkcamelvet@yahoo.com

49. Nutraceuticals in poultry health and diseases

 Begum Yurdakok Dikmen and Ayhan Filazi, Ankara University, Ankara,     

 Turkey

Email: byurdakok@yahoo.com

V. SAFETY AND TOXICITY EVALUATION OF FUNCTIONAL FOODS AND NUTRACEUTICALS

50. Safety and toxicity evaluation of nutraceuticals in animal models

Nikolay Goncharov, Russian Academy of Sciences, Saint Petersburg, Russia

Email: ngoncharov@gmail.com

51. Safety and toxicity evaluation of nutraceuticals using alternative in vitro      

 models 

 Subhash C. Gupta, Banaras Hindu University, Banaras, UP, India

Email: subhashg167@gmail.com

52. Safety of pet food, functional food, and nutraceuticals

Sandra James-Yi, Now Health Group, Inc., Bloomingdale, IL, USA

Email: Sandra.james-yi@nowfoods.com

53. Hydrocolloids: safety and toxicity considerations

Larry J. Thompson, Nestle Purina PetCare, St. Louis, MO, USA

Email: larry.thompson@rdmo.nestle.com

54. Biomarkers for selected foods  and nutraceuticals

Ramesh C. Gupta, Murray State University, Hopkinsville, KY, USA

Email: rgupta@murraystate.edu

55. Toxic interaction of nutraceuticals with food and pharmaceuticals

 Ramesh C. Gupta, Murray State University, Hopkinsville, KY, USA

 Email: rgupta@murraystate.edu

 Rhian B. Cope, Health Product Regulation Group, Woden ACT, Australia

 Email: rhian.Cope@health.gov.au

VI. NUTRACEUTICAL PRODUCT DEVELOPMENT

56. Nutraceuticals palatability process and study

Ajay Srivastava, Vets Plus Inc, Menomonie, WI, USA

 Email: drajay@vets-plus.com

57. Steps to conduct nutraceutical clinical efficacy trials 

Isabelle Mougeot, CanCog technologies Inc, Toronto, ON, Canada

Email: isabellem@cancog.com

58. Nutraceuticals stability study

Dan Duberdieu, Vets Plus Inc, Menomonie, WI, USA

Email: dand@vets-plus.com

VII. NEWER TRENDS IN NUTRACEUTICAL RESEARCH

59. Nanosupplements  and animal health

Francesca Caloni, Universita degli Studi di Milano, Milan, Italy

Email: francesca.caloni@unimi.it

60. Fabrication and use of nanoparticles in delivery of dietary ingredients and nutraceuticals to biological system

Gianfranco Risuleo, Sapienza University of Rome, Rome, Italy

Email: gianfranco.risuleo@gmail.com

61. Proteomics in evaluation of nutraceuticals and functional food

Christina R. Wilson, Dept. Comparative Pathology, Purdue University,          West Lafayette, IN, USA

Email: wilsonc@purdue.edu

62. Bioavailability of nutraceuticals

Gianfranco Risuleo, Sapienza University of Rome, Rome, Italy

Email: gianfranco.risuleo@gmail.com

VIII. REGULATORY ASPECT OF NUTRACEUTICALS

63. Role of AAFCO in functional food and nutraceutical regulations

Anita Sinha and Bill Bookout , Vets Plus Inc, Menomonie, WI, USA

Email: anitas@vets-plus.com and b.bookout@nasc.cc  

64. Role of NASC in functional food and nutraceutical regulations

Bill Bookout and Anita Sinha, Vets Plus Inc, Menomonie, WI, USA

Email: b.bookout@nasc.cc  and  anitas@vets-plus.com

65. Regulatory guidelines for nutraceuticals in the EU

Doriana Tedesco, Milano University, Milano, Italy

Email: Doriana.tedesco@unimi.it

66. US FDA’s perspective in regulation of veterinary nutraceuticals 

Daljit Vudathala, University of Pennsylvania, Kennet Square, PA, USA

Email: vudathal@vet.upenn.edu

67. Regulatory guidelines for nutraceuticals in Australia and New Zealand

 Rhian B. Cope, Health Product Regulation Group, Woden ACT, Australia

 Email: rhian.Cope@health.gov.au

68. Regulatory guidelines for nutraceuticals and food supplements in India

 Pawan K. Gupta, Bareilly, India

 Email: drpkg_brly@yahoo.co.in

69. Regulatory guidelines for nutraceuticals in China

Yet to be assigned

 Email:

70. Regulatory guidelines for nutraceuticals and food supplements in Turkey

 Begum Yurdakok Dikmen, and Ayhan Filazi, Ankara University, Ankara, 

 Turkey

 Email: byurdakok@yahoo.com

71. Uses and regulatory guidelines of nutraceuticals in Philippines

Jacob A. C. Sanchez, Pampanga State Agricultural University, Pampanga, Philippines

Email: jacobsanchezph1@gmail.com

72. Regulatory guidelines for nutraceuticals in South America

Yet to be assigned

 Email:

73. Regulatory guidelines for nutraceuticals in South Africa

Vinny Naidoo, University of Pretoria, Onderstepoort, Republic of South 

Africa

Email: vinny.naidoo@up.ac.za

O autorze

Dr. Ramesh C. Gupta serves as Professor and Head of the Toxicology Department at the Murray State University Breathitt Veterinary Center. He earned his DVM, MVSc, and PhD in India, and carried out his postdoctoral training at Michigan State University and Vanderbilt University, US. His research has addressed experimental brain research in relation to pesticide toxicity and neurological diseases; he has further been heavily engaged in veterinary nutraceuticals research. Dr. Gupta has held worldwide presentations and served on the panels of NIH, CDC, NIOSH, and NAS. He has published >400 publications, including 7 major books. In 2006, he received the Murray State University Distinguished Researcher Award; and in 2014, the Outstanding Research Award. He is a Diplomate of the American Board of Toxicology, and Fellow of the American College of Toxicology, American College of Nutrition, and Academy of Toxicological Sciences. Currently, he holds active membership in more than a dozen academic societies.

Dr. Ajay Srivastava is Chief Scientific Officer at Vets Plus Inc., and serves as an adjunct Faculty member at University of Wisconsin-Stout, Menomonie, US. He is specialized in preclinical and clinical product development and nutraceutical research. After receiving his BS in Biological Sciences, Dr. Srivastava earned his DVM from the School of Veterinary Medicine at GB Pant University of Agriculture and Technology, India, before pursuing his MS in Pharmacology. He completed his PhD in Neuropharmacology from All India Institute of Medical Sciences, New Delhi. After his post-doctoral training in preclinical drug development in neurological disorders, Dr. Srivastava became Senior Research Scientist of the Anticonvulsant Drug Development Program at the University of Utah, where he developed a novel animal model of pharmacoresistant epilepsy to screen potential antiepileptic drugs. He is one of the pioneer researchers who discovered the role of nutraceuticals resveratrol and melatonin in epilepsy. Dr. Srivastava has chaired various scientific sessions in AVMA and WVC meetings and has published several research articles in peer reviewed journals. He has contributed chapters in textbooks on epilepsy, toxicology and nutraceuticals.

Mr. Rajiv Lall is the Founder and CEO of Vets Plus, Inc., an international leader in the animal health industry. He graduated with two masters degrees, the first in Botany from his native country of India, and the second in Pharmacognosy/Medicinal Chemistry from the University of Minnesota. His research focused on identifying, analyzing, and extracting natural ingredients from plants and plant tissue cultures that provide natural health and medicinal properties, as well as on enzymes in relation to cancer cells through animal cell cultures. Mr. Lall started his career in the human health food industry with an emphasis on probiotics. His relentless drive continues to champion animal health through scientific research and the development of nutritional products and pharmaceuticals, and through these efforts he has obtained various patents and developed several hundred products. His company, Vets Plus, Inc. is a research and science-based product development company with a strong quality and manufacturing platform to support partners in Europe and around the world. Recent awards include the Pet Age Icon Award (2015), NASC Visibility Award (2015), and Menomonie Area Chamber of Commerce Business of the Year Award (2015). Vets Plus Inc. was also nominated for Wisconsin Manufacturer of the Year in 2015. In support of the animal health industry, Mr. Lall is now Founder and CEO of Noble Pharma, LLC, a pharmaceutical company in Menomonie, Wisconsin. Mr. Lall and his wife Swati are involved in philanthropic efforts and through that they have developed the Raj and Swati Lall Microbiology Laboratory at the University of Wisconsin-Stout in support of future scientists and business leaders and the community in Menomonie, Wisconsin.

Blurb

This unique work compiles the latest knowledge around veterinary nutraceuticals, commonly referred to as dietary supplements, from ingredients to final products in a single source. More than sixty chapters organized in seven sections collate all related aspects of nutraceutical research in animal health and disease, among them many novel topics: common nutraceutical ingredients (Section-I), prebiotics, probiotics, synbiotics, enzymes and antibacterial alternatives (Section-II), applications of nutraceuticals in prevention and treatment of various diseases such as arthritis, periodontitis, diabetes, cognitive dysfunctions, mastitis, wounds, immune disorders, and cancer (Section-III), utilization of nutraceuticals in specific animal species (Section-IV), safety and toxicity evaluation of nutraceuticals and functional foods (Section-V), recent trends in nutraceutical research and product development (Section-VI), as well as regulatory aspects for nutraceuticals (Section-VII). The future of nutraceuticals and functional foods in veterinary medicine seems bright, as novel nutraceuticals will emerge and new uses of old agents will be discovered.

International contributors to this book cover a variety of specialties in veterinary medicine, pharmacology, pharmacognosy, toxicology, chemistry, medicinal chemistry, biochemistry, physiology, nutrition, drug development, regulatory frameworks, and the nutraceutical industry. This is a highly informative and carefully presented book, providing scientific insight for academia, veterinarians, governmental and regulatory agencies with an interest in animal nutrition, complementary veterinary medicine, nutraceutical product development and research.