Nitric Oxide Donors: Novel Biomedical Applications and Perspectives

ISBN-13: 9780128092750 / Angielski / Miękka / 2017 / 364 str.

Amedea Seabra

Opis

Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology. Although considerable innovative progress has been achieved using Nitric Oxide donors in biomedical applications, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications. This book encompasses several topics on nitric oxide such as its sources and biological properties; its performance in the cardiovascular and neurologic systems, in the human skin and its application in the treatment of neglected diseases, neurodegenerative disorders, and cancer. Additionally, it covers its role in inflammation and immunity, penile erection function, photodynamic therapy, antimicrobial activities. It also discusses the future of nitric oxide donors in combination with other therapeutic drugs, in implantable sensors, and nitric oxide releasing hydrogels and medical devices for topical applications. The book is a valuable source for researchers on different areas of biomedical field who are interested in the improvements that these molecules can make in the treatment of several conditions.

• Provides background information about biology and chemistry of nitric oxide
• Discusses the state-of-the-art in the design of nitric oxide releasing nanomaterials for biomedical applications
• Covers the usage of nitric oxide donors in the treatment of several conditions, such as cancer, human skin, cardiovascular system, and immunity
• Discusses the future of nitric oxide donors and their FDA approval

Spis treści

1. Nitric Oxide Derivative Ruthenium Compounds as NO-Based Chemotherapeutic and Phototherapeutic Agents2. Nitric Oxide Donors for Treating Neglected Diseases3. Nitric Oxide-Donating Devices for Topical Applications4. Nitric Oxide Donors and Therapeutic Applications in Cancer5. Nitric Oxide Donors and Penile Erectile Function6. Nitric Oxide Donors in Nerve Regeneration7. Nitric Oxide Donors as Antimicrobial Agents8. Improving the Performance of Implantable Sensors with Nitric Oxide Release9. Strategies to Deliver Nitric Oxide Donors to Control Biofilms of Clinical and Industrial Interest10. Developing New Organic Nitrates for Treating Hypertension11. Nitric Oxide Donors in Brain Inflammation12. Synergistic Activities of Nitric Oxide and Various Drugs13. Hydrogels for Topical Nitric Oxide Delivery