Neurodegenerative Disorders: Loss of Function Through Gain of Function

ISBN-13: 9783642074486 / Angielski / Miękka / 2010 / 189 str.

K. Beyreuther;Y. Christen;C.L. Masters

Opis

Fondation Ipsen sponsored a meeting in Paris in February 2000 on the emerging paradigm-shift in our understanding of the major degenerative diseases which affect the aging human brain. This book sumarizes our deliberations on some of these major neurodegenerative diseases that are characterized by protein depos its, and that are due to the pathogenic gain of function of an otherwise normal neuronal protein. For each of the major human neurodegenerative diseases covered in this book -the most prominent being Alzheimer's disease -experimental models are described, including cell culture systems and animal models which range from the round worm, Caenorhabditis elegans, the fruitfly, Drosophila melanogaster, to rodents. Remarkably, in the sporadic forms of these human diseases, only a minor change in the level of production or turn-over of the relevant proteins is sufficient to cause disease in late adult-hood. Neurodegeneration in Alzheimer's disease, for example, usually results in symptoms and signs in the seventh to eighth decades. In contrast, the development of protein deposits in transgenic mice over-expressing the corresponding disease gene parallels the genetic forms of the human diseases in regard to its manifestation occuring half-way through its normal life-span, i. e. about 50 years in humans (the so-called "presenium") and 9 to 12 months in the mouse. Nevertheless, these models have served to elu cidate many of the pathways underlying the human disease processes, for instance clarifying the neuronal origin of parenchymal and perivascular amyloid in Alzheimer's disease and Creutzfeldt-Jakob disease."

Spis treści

The natural history of Alzheimer's Disease: minding the gaps in understanding the mechanisms of neurodegeneration.-Pathological mechanisms in Huntingdon's Disease and other polyglutamine expansion diseases.-Prion protein biogenesis: implications for neurodegeneration.-The value of transgenic models for the study of neurodegenerative diseases.-Pathogenesis and mechanisms of cerebral amyloidosis in APP transgenic mice.-The next step in Notch processing and its relevance to amyloid precursor protein.-The putative role of presenilins in the transmembrance domain cleavage of amyloid precursor protein and other integral membrane proteins.-ApoE receptor in the brain: novel signaling pathways with potential relevance for Alzheimer's Disease.-Homeoprotein intercellular transport: mechanisms,significance and applications.-And other contributions

Blurb

A fundamental change is occurring in the understanding of the major neurodegenerative disorders. Protein aggregation is a common emerging theme in diseases as diverse as Alzheimer's, Creutzfeld-Jakob, Parkinson's, and amyotrophic lateral sclerosis. If valid, then a small number of diagnostic and rational therapeutic strategies will emerge over the next few years, based on the common theme of modulation of the production, turnover and deposition of these aggregating proteins. The book provides insights into the cellular and animal models of these diseases, and how the molecular basis of neurodegeneration has become the preferred target of therapy.