Mucoadhesive Formulation and Evaluation of Terbutaline Sulphate Tablet

ISBN-13: 9783659374005 / Angielski / Miękka / 2013 / 64 str.

Chanda Ranabir;Samanta Saumya;Chakraborty Pranabesh

Opis

Bioadhesive polymers that bind to the gastric mucin or epithelial cell surface are useful in drug delivery for the purpose of (a) retaining a dosage form in the G.I tract and (b) increasing the intimacy and duration of contact of drug with the absorbing membrane. In this investigation, natural mucoadhesive materials were isolated from different edible fruits like Aegle marmelos (Linn.) Cor., Zizyphus mauritiana and Tamarindus indica by hot extraction method. Density and swelling property of natural materials were evaluated. Bioadhesive and mucoadhesive qualities of natural materials were evaluated individually by different in vitro testing methods and in vivo X-ray photograph method. It was observed that natural materials have good mucoadhesive property. Mucoadhesive tablets containing 7.5 mg of terbutaline sulphate tablets were prepared by wet granulation method. The sustained release pattern was evaluated by in vitro and in vivo studies. The drug release data were plotted using various kinetic equations (zero order, first order, Higuchis kinetics.Finally we confirmed our investigation by invitro-invivo correlation study.

O autorze

Ranabir Chanda is working as Asst. Professor in Bengal School of Technology, West Bengal, India.He is author of more than 300 articles in different international journals. He has presented his research papers in different international conference including prestigious Commonwealth Pharmaceutical Association Conference,2007, Kuala Lumpur.Malaysia.