1. Clinical features, differential diagnosis and pathology Michael van Es 2. Recent advances in genetics of familial and sporadic ALS Ammar Al Chalabi 3. Non-coding genome contribution to ALS John Cooper-Knock 4. Contribution of neurophysiology to the diagnosis and monitoring ALS James Alix 5. Advances in symptom management and monitoring disease progression Chris McDermott 6. Use of biomarkers in clinical trials and future developments that will help identify new biomarkers Andrea Malaspina 7. Application of systems biology to identify therapeutic targets Janine Kirby and Bryan Traynor 8. Evidence of mitochondrial dysfunction (in ALS) and how to measure it in model systems Heather Mortiboys and Kurt de Vos 9. Current neuroprotective therapies and future prospects Pamela Shaw 10. The role of glial cells in ALS Rickie Patani 11. Dysregulation of RNA biology in ALS Guillaume Hautbergue 12. New developments in pre-clinical models of ALS to guide translation Ludo van den Bosch
