Molecular Basis of Thyroid Cancer

ISBN-13: 9781402081064 / Angielski / Twarda / 2005 / 444 str.

Nadir R. Farid

Opis

Thyroid cancer is the fastest growing cancer in the U.S., especially among women. Given the relative success we have had in its treatment, there is a need to capitalize on it by better understanding the factors that underpin this malignancy, and exploring better strategies for diagnosis, treatment, and follow-up. To do so, we must take full advantage of the revolution in modern biology. This comprehensive volume addresses the needs of a broad readership. Against a backdrop of the complexity of the origins of cancer, pathology of thyroid tumors, including lymphomas, is discussed, as are molecular genetic lesions associated with spontaneous and radiation-related thyroid tumors, diagnostic tests available to surmise tumor subtypes (including a review of the potential of DNA micro arrays), advances in therapeutics (including recombinant hTSH superagonists, allowing for better treatment of well differentiated thyroid carcinoma and its imaging), and combinations of drugs that might influence the course of poorly differentiated and anaplastic thyroid cancer. In this book, we glimpse into the promise of gene therapy in the future management of otherwise lethal anaplastic and poorly differentiated thyroid tumors. The molecular genetics of medullary thyroid cancer is considered in depth, and malignancy is used as a showcase for genetic prediction and counseling.

Recenzje

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Reviewer's Expert Opinion: Ronald N Cohen, MD (University of Chicago Medical Center)

This book discusses and evaluates recent advances in the molecular basis of the pathogenesis and treatment of the various forms of thyroid cancer. The purpose is to convey a better understanding of the factors that cause thyroid cancer, as well as to explore novel strategies for its treatment, focusing on recent advances in molecular biology. There is a significant, and rapidly-growing, literature concerning the molecular biology of thyroid cancer, and this book is a welcome addition that allows these novel findings to be placed in perspective. There will be a relatively narrow audience for this book. In particular, it will appeal significantly more to thyroidologists than to general endocrinologists. In addition, it will be interesting to nuclear medicine physicians, pathologists, and oncologists if they have a specific interest in thyroid cancer. The book covers a wide range of topics, ranging from the pathology of thyroid tumors to specific molecular events in the pathogenesis of thyroid cancer. In this process, chapters devoted to specific molecules important in thyroid cancer are included. In addition, information on NIS, and how it relates to thyroid cancer imaging and treatment is discussed in detail. Finally, molecular genetics, for example the genetics of medullary thyroid cancer, is also included. The chapters are well written and informative, though there is occasional overlap. For physicians and scientists with a significant interest in thyroid cancer, this book is a welcome addition. It provides a wealth of interesting information, and I enjoyed it very much.

Spis treści

Preface 1. The origin of cancer, Evan Y. Yu and William C. Hahn 2. The pathology of thyroid cancer; Sylvia L. Asa 3. Thyroid lymphomas; Runjan Chetty 4. Molecular events in follicular thyroid tumors; Todd G. Kroll 5. Molecular epidemiology of thyroid cancer; Martin Schlumberger 6. Growth factors and their receptors in the genesis and treatment of thyroid cancer; Shereen Ezzat 7. Biology of Ras in thyroid cells; Judy L. Meinkoth 8. P53 and other cell cycle regulators; Nadir R. Farid 9. Abnormalities of nuclear receptors in thyroid cancer; Sheue-Yann Cheng 10. Matrix metalloproteinases in thyroid cancer; Yufei Shi and Minjing Zou 11. The molecular pathways induced by radiation and leading to thyroid carcinogenesis; Yuri E. Nikiforov 12. TRK oncogenes in papillary thyroid carcinoma; Angela Greco, Emanuela Roccato and Marco A. Pierotti 13. Thyroidal iodide transport and thyroid cancer; Orsolya Dohán and Nancy Carrasco 14. Molecular signaling in thyroid cancer; Nicholas J. Sarlis and Salvatore Benvenga 15. Gene expression in thyroid tumors; Laszlo Puskas and Nadir R. Farid 16. Animal models of thyroid carcinogenesis; Carsten Boltze 17. Diagnostic molecular markers in thyroid cancer; Matthew D. Ringel 18. Thyroid cancer imaging; T.T.H. Phan, P.L. Jager, K.M. van Tol, T.P. Links 19. Past, presence and future of thyroid-stimulating hormone (TSH) superactive analogs; Mariusz W. Szkudlinski 20. Pathobiology of antineoplastic therapy in undifferentiated thyroid cancer; Kenneth B. Ain 21. Gene therapy for thyroid cancer; Yuji Nagayama 22. Familial papillary thyroid carcinoma; Carl D. Malchoff and Diana M. Malchoff 23. RET activation in medullary carcinomas; Marco A. Pierotti, Elena Arighi, Debora Degl’Innocenti and Maria Grazia Borrello 24. From genes to decisions; Lois M. Mulligan

Blurb

Thyroid cancer shows the fastest rate of increase in women in the USA. There is an urgent need to better understand its underlying causes, explore efficient and sensitive methods for its diagnosis, new methods of treatment and follow-up, based on the recent advances in technology.

Molecular Basis of thyroid Cancer brings together top-flight experts from across the globe to consider present state of the art treatment and techniques and what the future holds. The product of this effort is invaluable to endocrinologists, particularly those with an interest in the thyroid, molecular oncologists, nuclear medicine physicians and those in biotechnology intent on devising innovative therapies for cancer.

"Significant advances in our understanding of thyroid cancer have occurred over the previous decade. This text discusses the molecular alterations and pathologic manifestations seen in this disease. Distinguished investigators address both the basic biology and clinical issues pertinent to our understanding and management of patients with thyroid cancer."

Steven T. Rosen, M.D.

Series Editor