Molecular Bases of Axonal Growth and Pathfinding

ISBN-13: 9783540635222 / Angielski / Miękka / 1997 / 283 str.

Drescher; U. Drescher

Opis

This special edition of CTR, volume 290/2, deals with the molecular bases of axonal growth and pathfinding. Chapters cover areas including: the role of morphogenetic genes and transcription factors in axon tract formation; and semaphorins and other repulsive guidance cues.

Spis treści

Editorials.- Axonal pathfinding — special.- Axonal growth and pathfinding: from phenomena to molecules.- Role of morphogenetic genes and transcription factors in axon tract formation.- Analysis of axon tract formation in the zebrafish brain: the role of territories of gene expression and their boundaries.- Pax-2 in the chiasm.- Eph receptors and their ligands.- Functional guidance components and their cellular distribution in retinotectal co-cultures.- Genetic analysis of the role of Eph receptors in the development of the mammalian nervous system.- The Eph family: a multitude of receptors that mediate cell recognition signals.- Ephrins and their receptors: a repulsive topic?.- Multiple roles of Eph-like kinases and their ligands during development.- Regulation of topographic projection by the Eph family receptor Bsk (EphA5) and its ligands.- A link between axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor EphA5/REK7 and its ligand EphrinA5/AL-1.- Roles of Eph receptors and ephrins in neural crest pathfinding.- Semaphorins and other repulsive guidance cues.- Axon guidance and somites.- Neurotrophins as in vitro growth cone guidance molecules for embryonic sensory neurons.- Patterning neuronal connections by chemorepulsion: the semaphorins.- How do wiring molecules specify cortical connections?.- Extracellular matrix components.- Dual role of Cajal-Retzius cells and reelin in cortical development.- Guidance of circumferentially growing axons by the floor plate in the vertebrate central nervous system.- The tenascin gene family in axon growth and guidance.- Chondroitin sulfate proteoglycans as mediators of axon growth and pathfinding.- Modeling an extracellular environment for axonal pathfinding and fasciculation in the central nervous system.- Synaptic differentiation: the role of agrin in the formation and maintenance of the neuromuscular junction.- Neuronal extracellular proteases facilitate cell migration, axonal growth, and pathfinding.- Neuron-glia interactions in axogenesis and regeneration.- Astrocytic and neuronal factors affecting axon regeneration in the damaged central nervous system.- Glial cell extracellular matrix: boundaries for axon growth in development and regeneration.- Mechanisms of astrocyte-directed neurite guidance.- Growth characteristics of ganglion cell axons in the developing and regenerating retino-tectal projection of the rat.- Cell adhesion molecules.- Cadherins and the formation of neural circuitry in the vertebrate CNS.- The role of cell adhesion molecule L1 in axonal extension, growth cone motility, and signal transduction.- Nr-CAM: A cell adhesion molecule with ligand and receptor functions.- Axonin-1 and NgCAM as “recognition” components of the pathway sensor apparatus of growth cones: a synopsis.- Molecular mechanisms of growth cone guidance: stop and go?.- CAMs and the FGF receptor: an interacting role in axonal growth.- Basic principles and molecular mechanisms of olfactory axon pathfinding.- Roles of a neuronal cell-surface molecule, neuropilin, in nerve fiber fasciculation and guidance.