Modern Vaccinology

ISBN-13: 9780306448201 / Angielski / Twarda / 1994 / 398 str.

Eduard Kurstak; Edouard Ed. Kurstak; Eduard Kurstak

Opis

The recent developments in modern vaccinology are mainly based on: (i) cloning of microbial genes into recombinant vectors containing genetic information for expression of desired neutralizing immunogens; (ii) alternatives of attenuated vectors with deleted genes permitting the insertion of several foreign genes expressing antigens exposed to the host immune system during the abortive replication of such vectors; (iii) combined vaccines with the aim to protect against many diseases with a limited number of administrations; (iv) evidence demonstrating the ability of animals to respond serologically to DNA injections considered as a potential method of vaccination; (v) the possibility to manipulate the immune system with new and improved immunomodulators enhancing the immune response; and (vi) new microcarrier systems for particular immunogens or immunomodulators delivery, either in a single dose or sustained release, and presentation to the immune system for a relevant response. New vaccines being developed are mainly based on viral, bacterial or other vectors modified with genetic engineering technology, to possess and express desired antigens for vaccination against single or multiple infections. Existing combined vaccines like diphtheria, tetanus, pertussis (DTP) are also experimented with new additional components like recombinant hepatitis B virus surface antigen, inactivated poliovirus, and Haemophilus inJluenzae type b immunogens, in order to produce multivalent vaccines. Such types of vaccines permitting the reduction of multiple medical visits is of particular interest to pediatric immuni zation programs, and would benefit especially the developing countries assuring better vaccine compliance with immunization schedules.

Spis treści

New Concepts in Vaccines Development and Immune Response: Vaccination with Polynucleotides (J.B. Ulmer et al.). Development of Vaccines by Grafting Microbial Epitopes in Immunoglobulins (C.A. Bona). Conventional and New Generation Combined Vaccines (F.E. André et al.). Progress in the Development of Multivalent Oral Vaccines Based on Live Attenuated Salmonella (S.N. Chatfield et al.). Potentiation of Vaccines through Effective Adjuvant Formulations and Manipulation of the Immune Response (H.P.A. Hughes, L.A. Babiuk). Recombinant Vaccines and Multivalent Immunogens: Recent Advances in Recombinant Vaccines for Viral and Parsitic Diseases (J.A. Tine et al.). Hepatitis B Virus Recombinant Vaccines (F. Tron). Recombinant Hepatitis B Surface Antigen as Carrier of Human Immunodeficiency Virus Epitopes (K. Schlienger et al.). Genetically Engineered Human Immunodefiency Virus Type1 Vaccines (B. Rovinski, M. Klein). 9 additional articles. Index.