Modern Genome Annotation: The Biosapiens Network

ISBN-13: 9783211999110 / Angielski / Miękka / 2010 / 490 str.

D. Frishman; Alfonso Valencia

Opis

An accurate description of current scientific developments in the field of bioinformatics and computational implementation is presented by research of the BioSapiens Network of Excellence. Bioinformatics is essential for annotating the structure and function of genes, proteins and the analysis of complete genomes and to molecular biology and biochemistry. Included is an overview of bioinformatics, the full spectrum of genome annotation approaches including; genome analysis and gene prediction, gene regulation analysis and expression, genome variation and QTL analysis, large scale protein annotation of function and structure, annotation and prediction of protein interactions, and the organization and annotation of molecular networks and biochemical pathways. Also covered is a technical framework to organize and represent genome data using the DAS technology and work in the annotation of two large genomic sets: HIV/HCV viral genomes and splicing alternatives potentially encoded in 1% of the human genome.

Spis treści

-Bioinformatics in Europe and the Biosapiens Network:-Gene definition; State of the art in eukaryotic gene prediction; Quality control of gene predictions:-Gene regulation and expression; Evaluating methods for protein-DNA interactions. Rationalisation of protein-DNA binding data: a biophysical approach; Annotating the human transcriptome:-Genome variation; Annotation and Genetics:-Functional annotation of proteins; Resources for functional annotation; Annotation of bacterial genomes; Data mining in genome annotation;Protein Families;Sequence to Function;Structure to Function;Molecular Class Specific Information Systems:-Protein structure prediction;Structure prediction of globular proteins;The state of the art of membrane protein structure prdiction:from sequence to 3D structure:- Protein-protein complexes, pathways and networks;Metabolic pathways, enzymes;Protein-proteine interactions;Predicting protein networks from genomic data:- Infrastructure for distributed protein annotation:-Applications;Viral bioinformatics;The ENCODE project