Microglia in the Regenerating and Degenerating Central Nervous System

ISBN-13: 9781441929440 / Angielski / Miękka / 2011 / 315 str.

Wolfgang J. Streit

Opis

Over the past decade, the study of microglial cells has gained increasing importance, in particular for those working in the fields of degeneration and regeneration. Microglia in the Regenerating and Degenerating CNS supports the assertion that understanding microglial biology could perhaps be pivotal for unraveling the pathogenetic mechanisms that underlie Alzheimer's disease, currently the most widely studied disorder of the central nervous system. In addition, microglia are also critical for understanding the sequelae of traumatic brain and spinal cord injury, and for the vitally important post-traumatic repair processes. This book gives an up to date account of the role of microglia in degeneration and regeneration of the nervous system and also reviews microglial cell function and physiology. Cellular neurobiologists will find that this is a valuable guide to the importance and role of microglia in the CNS.

Spis treści

Foreword * Section I. Microglial Physiology * Physiology and Pathophysiology of Microglial Cell Function by Wolfgang J. Streit * Roles of Microglia in the Developing Visual System by Julio Navascues, Miguel A. Cuadros, Ruth Calvente, Jose L. Marin-Teva * Microglial Ion Channels by Claudia Eder * Calcium Signaling in Microglial Cells by Thomas Muller * Microglia as a Source and Target of Cytokine Activities in the Brain by Uwe-Karsten Hanisch * Section II. Acute CNS Injury and Repair * Microglia and Macrophage Responses in Cerebral Ischemia by Guido Stoll, Sebastian Jander, Michael Schroeter * Role of Microglia and Macrophages in Secondary Injury of the Traumatized Spinal Cord: Troublemakers or Scapegoats? by Phillip G. Popovich * Microglial Response in the Axotomized Facial Motor Nucleus by Gennadij Raivich * Neuroprotective Roles of Microglia in the Central Nervous System by Kazuyuki Nakajima, Shinichi Kohsaka * Influences of Activated Microglia/Brain Macrophages on Spinal Cord Injury and Regeneration by Alexander G. Rabchevsky * Opportunities for Axon Repair in the CNS: Use of Microglia and Biopolymer Compositions by Joshua B. Stopek, Wolfgang J. Streit, Eugene P. Goldberg * Section III. Alzheimer's Disease and Aging * Beta Amyloid Protein Clearance and Microglial Activiation by Sally A. Frautschy, Greg M. Cole, March D. Ard * Microglia and Aging in the Brain by Caleb E. Finch, Todd E. Morgan, Irina Rozovsky, Zhong Xie, Richard Weindruch, Tomas Prolla * Index