Mechanisms of Oncogenesis: An Update on Tumorigenesis

ISBN-13: 9789400732117 / Angielski / Miękka / 2012 / 314 str.

Domenico Coppola

Opis

Thisvolumeisacontinuationoftheencyclopedicworkentitled CancerGrowthand Progression, thatwasoriginallyeditedbyProfessorHansE. Kaiser. Asatributeto thememoryofDr. Kaiserandhiscontributionstothe eld, thisneweditionisf- lowinghisexampleofprovidingthemostcurrentinformationaboutcancerliterature andcomprehensivecoverageofallaspectsoftumorgrowthandprogression. Thisparticulartomeisdividedintotwosections: the rstaddressinggeneralcauses ofoncogenesissuchasenvironmentalfactorsandtumormechanisms;andthesecond addressingtheoncogenicmechanismsoftumorinspeci corgans. Thisbookiswr- tenandcompiledbyworldrenownedleadersintheirrespective eldsandfocuseson themostrecentdevelopmentsinbasiconcogenesis. Thisde nitivetextwillprovide thepractitioner, whetherinresearch, academiaorclinicalpractice, withafountof easilyaccessibleinformationonthemostcommontumors. v Contents 1 Cytokines and Stressors: Implications for Cancer Immunotherapy 1 AlexanderW. KusnecovandHymieAnisman 2 The Role of Oncogene Activation in Tumor Progression. . . . . . . 19 MichaelJ. GrayandGaryE. Gallick 3 Carcinogenic Effects of Ionising Radiation. . . . . . . . . . . . . . 43 ArthurC. Upton 4 Chemical Carcinogenesis Role of Chloroform Further Studies. . 63 ElizabethK. Weisburger 5 Use of Organ Explant and Cell Culture in Cancer Research . . . . 71 EricJ. Kort, ChristineR. Moore, EricA. Hudson, BrandonLeeser, JamesH. Resau, G. M. Yerushalmi, R. Leibowitz-Amit, GaliaTsarfaty, IlanTsarfaty, andSharonMoskovitz 6 Chromosomal Abnormalities in Selected Hematopoietic Malignancies Detected by Conventional and Molecular Cytogenetics: Diagnostic and Prognostic Signi cance. . . . . . . . 89 HonFongL. Mark, SusanaC. Raimondi, andRobertSokolic 7 Mechanisms of Cancer Growth and Progression in Lymphoma. . . 115 MojdehNaghashpourandLynnC. Moscinski 8 Pediatric Cancer Mechanisms of Cancer Growth and Progression . 129 EnidGilbert-BarnessandPawiniKhanna 9 Carcinogenetic Pathway of Malignant Melanoma . . . . . . . . . . 149 KennethB. CalderandMichaelB. Morgan 10 Ewing Sarcoma: Molecular Characterization and Potential Molecular Therapeutic Targets . . . . . . . . . . . . . . . . . . . . 159 MarilynM. BuiandPaulJ. Zhang 11 Molecular Mechanisms of Central Nervous System Metastasis. . . 167 NicoleD. Riddle, MumtazVRojiani, StevenBrem, andAmynM. Rojiani 12 Carcinogenesis of Human Papillomavirus in Head and Neck Squamous Cell Carcinoma. . . . . . . . . . . . . . . . . . . . 179 DahuiQin vii viii Contents 13 Postmenopausal Hormone Replacement Therapy and Breast Cancer Clinicopathologic Associations and Molecular Mechanisms . . . . . . . . . . . . . . . . . . . . . . 187 GezaAcsandMichaelJ. Wagoner 14 Carcinogenesis of Lung Cancer . . . . . . . . . . . . . . . . . . . . 203 JeffreyAufmanandFarahKhalil 15 Genesis of Barrett s Neoplasia: Current Concepts. . . . . . . . . . 213 DomenicoCoppola, NellyA. Nasir, andLeslieTurner 16 Genesis of Pancreatic Ductal Neoplasia. . . . . . . . . . . . . . . . 225 BarbaraA. CentenoandGregoryM. Springett 17 Recent Advances in the Pathogenesis of Pancreatic Endocrine Neoplasms. . . . . . . . . . . . . . . . . . . . . . . . . . 237 OmieMills, NellyA. Nasir, JonathanR. Strosberg, La

Spis treści

1. Cytokines and Stressors: Implications for Cancer Immunotherapy; Alexander W. Kusnecov and Hymie Anisman 2. The Role of Oncogene Activation in Tumor Progression; Michael J. Gray and Gary E. Gallick 3. Carcinogenic Effects of Ionising Radiation; Arthur C. Upton 4. Chemical Carcinogenesis Role of Chloroform – An Update; Elizabeth K. Weisburger 5. Use of Organ Explant and Cell Culture in Cancer Research; Eric J. Kort, Christine R. Moore, Eric A. Hudson, Brandon Leeser, James H. Resau, G.M. Yerushalmi, R. Leibowitz-Amit, Galia Tsarfaty, Ilan Tsarfaty and Sharon Moskovitz 6. Chromosomal Abnormalities in Selected Hematopoietic Malignacies Detected by Conventional and Molecular Cytogenetics: Diagnostic and Prognostic Significance; Hon Fong L. Mark, Susana C. Raimondi and Robert Sokolic 7. Mechanisms of Cancer Growth and Progression in Lymphoma; Mojdeh Naghashpour and Lynn C. Moscinski 8. Pediatric Cancer Mechanisms of Cancer Growth and Progression; Pawini Khanna and Enic Gilbert-Barness 9. Carcinogenetic Pathway of Malignant Melanoma; Kenneth B. Calder and Michael B. Morgan 10. Ewing Sarcoma: Molecular Characterization and Potential Molecular Therapeutic Targets; Marilyn M. Bui and Paul J. Zhang 11. Molecular Mechanisms of Central Nervous System Metastasis; Nicole DeMers, Mumtaz V. Rojiani and Amyn M. Rojiani 12. Carcinogenesis of Human Papillomavirus in Head and Neck Squamous Cell Carcinoma; Dahui Qin 13. Postmenopausal Hormone Replacement Therapy and BreastCancer – Clinicopathologic Associations and Molecular Mechanisms; Geza Acs and Michael J. Wagoner 14. Carcinogenesis of Lung Cancer; Jeffrey Aufman and Farah Khalil 15. Genesis of Barrett’s Neoplasia: Current Concepts; Leslie Turner, Nelly A. Nasir and Domenico Coppola 16. Genesis of Pancreatic Ductal Neoplasia; Barbara A. Centeno and Gregory M. Springett 17. Recent Advances in the Pathogenesis of Pancreatic Endocrine Neoplasms; Omie Mills, Nelly A. Nasir, Johnathan A. Strosberg, Larry K. Kvols, Domenico Coppola, Aejaz Nasir 18. Mechanisms of Carcinogenesis in Colorectal Cancer; Shaokun Shu, Jin Q. Cheng 19. Carcinogenetic Pathway of Superficial Low-Grade Urothelial Carcinoma; Shang-Tian Chuang, Robert A. Tracy and Ximing J. Yang 20. Carcinogenetic Pathway of Urothelial Carcinoma; Shohreh Iravani Dickinson 21. Mechanisms of Carcinogenesis in Prostate Cancer; Jose J. Correa, Julio Pow-Sang 22. HPV in Cervical Carcinoma; Elizabeth Sagatys and Ardeshir Hakam Index

Blurb

This volume is part of a book series that was first published in 10-volumes by Kluwer in 1989 under the series editorship of Professor Hans E. Kaiser, D.Sc., former Professor of Pathology at the School of Medicine, University of Maryland at Baltimore, MD, USA along with other leaders in the field of Cancer. In order to encompass the growing body of knowledge on various aspects of cancer growth and progression since then, the series has now been expanded to 17 volumes.

This volume is a comprehensive update on the mechanisms of tumorigenesis, and includes the advances in the field, as provided by the use of the most recent molecular techniques (microarray, proteomic, and other omics). While the first portion of the book contains chapters discussing pediatric cancer, the influence of environmental factors and oncogene activity in tumorigenesis, the second portion of the book is structured by organ sites (Esophagus, Breast, Pancreas, Colon, Lung, Prostate, Skin, Brain, Endocrine System, Lymphoid System, Bone, Head and Neck, and Cervix). This format provides the reader with easy access to the needed information.

This definitive text will offer the medical professionals, whether in research, academia or clinical practice, the latest information endorsed by the world renowned contributors. The broad range of topics will make this a valued reference and provide a wealth of information, making this a "state of the science" on carcinogenesis.