Mass Spectrometry in Drug Discovery

ISBN-13: 9780824706074 / Angielski / Twarda / 2001 / 432 str.

Rossi T. Rossi; David T. Rossi; Michael W. Sinz

Opis

Summarizes the theory, instrumentation, techniques, and application of mass spectrometry and atmospheric pressure ionization to screening, evaluating, and improving the performance and quality of drug candidates. This book demonstrates the use of mass spectrometry in the assessment of disease states, drug targets, and potential drug agents.

Recenzje

"…a comprehensive overview of the theory and applications of mass spectrometry in drug discovery…easy to read and contains clearly organized information…provides fast access to the desired information."
-ChemBioChem

Spis treści

Introduction: the demand for drug discovery today; the impact of atmospheric pressure ionisation. Part 1 Instrumentation: a mass spectrometry primer. Part 2 Experimental strategies: ion chemistry and fragmentation; the LC/MS experiment; sample preparation and handling for LC/MS in drug discovery. Part 3 Applications: mass spectrometry in combinatorial chemistry; drug hydrophobicity and transport; the mass spectrometer in drug metabolism; mass spectrometry-assisted applications of stable-labeled compounds in pharmacokinetic and drug metabolism studies; cassette dosing in drug discovery; applications of microdialysis/mass spectrometry to drug discovery; future directions for mass spectrometry in drug discovery.

O autorze

David T. Rossi