Intracellular Delivery II: Fundamentals and Applications

ISBN-13: 9789401788953 / Angielski / Twarda / 2014 / 479 str.

Ale Prokop; Yasuhiko Iwasaki; Atsushi Harada

Opis

This volume is a continuation of Volume 1 following the previously published Editorial. More emphasis is given to novel nanocarrier designs, their characterization and function, and applications for drug discovery and treatment. A number of chapters will deal with nanofibers as a new major application within the biomedical field with a very high success rate particularly in wound healing and diabetic foot and spine injuries. A major new subdivision will deal with mathematical methods for the assembly of nanocarriers both for simulation and function.

Spis treści

Editorial and Introduction to Volume 2
Aleš Prokop, Yasuhiko Iwasaki and Atsushi Harada

Part I Novel nanocarrier design and processing

Proprietary nanofiber technologies and scale-up
Stanislav Petřík

Magnetically responsive (nano)biocomposites
Ivo Šafařík, Kateřina Horská, Kristýna Pospišková, Zdenka Maděrová and Mirka Šafaříková

Zwitterionic nanocarriers for gene delivery
Yu-Ju Shih, Ching-Wei Tsai, Lemmuel L Tayo and Yung Chang 

Stimuli-responsive polymeric nanocarriers as promising drug and gene delivery systems
Gurusamy Saravanakumar and Won Jong Kim  

Photo-responsive polymeric nanocarriers for on-demand drug delivery
Jian Ji and Qiao Jin 

Part II Nanocarrier characterization and function

Considerations on uptake and intracellular trafficking of nanocarriers
Seyed Moien Moghimi, Helene Andersen and Ladan Parhamitar 

Mucus as physiological barrier to intracellular delivery
Eleonore Fröhlich and Eva Roblegg 

Investigation of nanoparticles in biological objects by electron microscopy techniques
Gabriela Kratošová, Kateřina Dědková, Ivo Vávra and Fedor Čiampor

Gold nanoparticles for high resolution imaging in modern immunocytochemistry
Adam Schröfel, Dušan Cmarko, Eva Bártová and Ivan Raška 

Design of functional polymers for intracellular drug nucleic acids delivery
Nobuhiro Nishiyama, Hiroyasu Takemoto 

Membrane-domain-selective drug targeting based on lipid modification
Takeshi Mori and Yoshiki Katayama

Multifuntional protein-based nanoparticles for theragnosis
Vannucci Luca, Elisabetta Falvo and Pierpaolo Ceci

Cytocompatible phospholipid polymer for noninvasive nanodevice
Tomohiro Konno 

Intracellular protein delivery using self-assembled amphiphilic polysaccharide nanogels
Asako Shimoda, Shin-ichi Sawada and Kazunari Akiyoshi 

Part III Simulation for delivery and function

Molecular dynamics simulations of polyplexes and lipoplexes
Deniz Meneksedag-Erol, Chongbo Sun, Tian Tang, and Hasan Uludag

Computational studies of highly pegylated sterically stabilized micelles self-assembly and drug solubilization
Lela Vukovic´ and Petr Král

Toward intracellular delivery and drug discovery
Stochastic logic networks as efficient computational models for gene regulatory networks
Peican Zhu, Jinghang Liang and Jie Han

Part IV Nanocarriers for drug discovery and treatment  

Nanodiamonds as intracellular probes for imaging in biology and medicine
Jitka Slegerová, Ivan Řehoř, Jan Havlík, Helena Raabová, Eva Muchová and Petr Cigler

Intracellular delivery of RNA using RNA-binding proteins or peptides
Kazunori Watanabe and Takashi Ohtsuki

Hyaluronic acid based nanofibers for wound dressing and drug delivery carriers
Jana Růžičková., Vladimíir Velebný, Jindřich Novák J., Katarzyna Szuszkiewicz, Kateřina Knotková,  Marcela Foglarová and Marek Pokorný

Potential of siRNA therapy in chronic myeloid leukemia
Juliana Valencia-Serna, Breanne Landry, Xiaoyan Jiang and Hasan Uludag