Integrated Drug Discovery Technologies

ISBN-13: 9780824706494 / Angielski / Twarda / 2002 / 576 str.

Houng-Yau Mei; Anthony W. Czarnik; Mei Mei

Opis

Integrated Drug Discovery Technologies provides a global overview of emerging drug development technologies by presenting and integrating new techniques from the disciplines of chemistry, biology, and computational sciences. It combines integration of contemporary mechanization with strategies in drug delivery. Topics include: functional genomics, microfabrication techniqes, integrated proteomics technologies, high throughput screening, and fluorescence correlation spectroscopy methods.

Spis treści

From gene to screen: target identification and validation Coupling Genotype to Phenotype; functional genomics; integrated proteomics technologies; where science meets silicone - microfabrication techniques and their scientific applications; SNP scoring for drug discovery applications; protein display chips; integrated proteomics technologies and in vitro validation of molecular tests. High throughput screening: high throughput screening as a discovery resource; fluorescence correlation spectroscopy (FCS) and FCS-related confocal fluorimetric methods (FCS + plus) multiple read-out options or miniaturized screening; homogeneous time-resolved fluorescence (HTRF); ADME-tox screening in drug discovery; screening lead compounds in the post-genomic era - an integrated approach to knowledge building from living cells.

O autorze

Mei, Houng-Yau; Czarnik, Anthony W.