Human Cell Transformation: Role of Stem Cells and the Microenvironment

ISBN-13: 9781493941643 / Angielski / Miękka / 2016 / 224 str.

Johng S. Rhim; Richard Kremer

Opis

This book explores the latest progress in cell transformation model systems, and explores molecular and cellular changes at work in the transformation of normal cells into neoplastic cells. Also covers stem cells, and the role of microenvironments in cancer.

Spis treści

Nuclear Barrier Hypothesis of Aging as Mechanism for Tradeoff Growth to Survival.- Establishment of Cell Lines from the Human Middle and Inner Ear Epithelial Cells.- Cellular Systems for Studying Human Oral Squamous Cell Carcinomas.- Heterotopic Ossification Following Musculoskeletal Trauma: Modeling Stem and Progenitor Cells in Their Microenvironment.- Comparative Proteomic Analysis of Mesenchymal Stem Cells Derived from Human Bone Marrow, Umbilical Cord, and Placenta: Implication in the Migration.- Novel Human Prostate Epithelial Cell Culture Models for the Study of Carcinogenesis and of Normal Stem Cells and Cancer Stem Cells.- Prostate Tumor Cell Plasticity: A Consequence of the Microenvironment.- Role of Epigenetics in Cancer Initiation and Progression.- Cancer Stem Cells, Models of Study and Implications of Therapy Resistance Mechanisms.- The Role of the Basal Stem Cell of the Human Breast in Normal Development and Cancer.- Breast Cancer Subtypes: Two Decades of Journey from Cell Culture to Patients.- Parathyroid Hormone Related Protein (PTHrP) in Tumor Progression.- Mechanism of Radiation Carcinogenesis: Role of the TGFBI Gene and The Inflammatory Signalling Cascade.- Histone Deacetylase Inhibitors: Anti-Neoplastic Agent and Radiation Modulator.- Human Fibroblasts for Large-Scale “Omics” Investigations of ATM Gene Function.- Malignant Transformation of Human Skin Fibroblasts by Two Alternative Pathways.- A Novel Tumor Suppressor, REIC/Dkk-3 Gene Identified By Our In Vitro Transformation Model of Normal Human Fibroblasts Works as a Potent Therapeutic Anti-Tumor Agent.