Hepatocellular Carcinoma: Translational Precision Medicine Approaches

ISBN-13: 9783030215392 / Angielski / Twarda / 2019 / 364 str.

Yujin Hoshida

Spis treści

Part 1: Clinical demographics and management

1. Risk Factors of Hepatocellular Carcinoma for Precision Personalized Care

Naoto Fujiwara, Po-Hong Liu, Sai Krishna Athuluri-Divakar, Shijia Zhu, Yujin Hoshida

2. Hepatocellular Carcinoma Surveillance and Staging

Amit G. Singal, Neehar D. Parikh, Nicole E. Rich, Binu V. John, Anjana Pillai

3. Changing Epidemiology of Hepatocellular Carcinoma and Role of Surveillance

Yueran Zhuo, Qiushi Chen, Jagpreet Chhatwal

Part 2: Diagnosis and prognostication

4. Radiological diagnosis and characterization of HCC

Naik Vietti Violi, Sara Lewis, Stefanie Hectors, Daniela Said, Bachir Taouli

5. Analysis of Hepatocellular Carcinoma Tissue for Biomarker and Therapeutic Target Discovery

Connor West, Alyson P. Black, Anand S. Mehta

6. Molecular subtypes and genomic signatures of hepatocellular carcinoma for prognostication and therapeutic decision making

Sung Hwan Lee, Sun Young Yim, Jae-Jun Shim, Ju-Seog Lee

7. Liquid Biopsy in Hepatocellular Carcinoma

Irun Bhan, Daniel A. Haber, Raymond T. Chung, David T. Ting

Part 3: Treatment

8. Surgical Therapies in Hepatocellular Carcinoma

Caitlin A. Hester, Adam C. Yopp

9. Interventional Radiologic Therapies for Hepatocellular Carcinoma: From Where We Began To Where We Are Going

Patrick D. Sutphin, Daniel Lamus, Sanjeeva P. Kalva, Junjie Li, Ian R. Corbin

10. Precision Locoregional Therapies for Hepatocellular Carcinoma: Percutaneous Ablation and Radiotherapy

Ryosuke Tateishi, Naoto Fujiwara

11. Molecular-targeted therapies in hepatocellular carcinoma

Amit Mahipal, Anuhya Kommalapati, Rutika Mehta, Richard Kim 

12. Immune therapies

Zachary J. Brown and Tim F. Greten

13. Prevention Strategies for Hepatocellular Carcinoma

Derek J. Erstad, Allen A. Razavi, Shen Li, Kenneth K. Tanabe, Bryan C. Fuchs

Part 4: Molecular pathogenesis and therapeutic discovery

14. Molecular Alterations and Heterogeneity in Hepatocellular Carcinoma

Hsin Hung, Xin Wei Wang

15. Stromal and Immune Drivers of Hepatocarcinogenesis

Antonio Saviano, Natascha Roehlen, Alessia Virzì, Armando Andres Roca Suarez, Yujin Hoshida, Joachim Lupberger, Thomas F. Baumert

16. Experimental Models for Preclinical Research in Hepatocellular Carcinoma

Pedro Molina-Sánchez, Amaia Lujambio

O autorze

Yujin Hoshida
University of Texas Southwestern Medical Center
Dallas, TX
USA

Blurb

This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields.

By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.