Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 1: Principles and Practice of Toxicologic Pathology

ISBN-13: 9780128210444 / Angielski / Twarda / 2022

Wanda M. Haschek; Colin G. Rousseaux; Matthew A. Wallig

Spis treści

1. Toxicology Pathology: An Introduction

Part 1 Principles of Toxicologic Pathology 2. Biochemical and Molecular Basis of Toxicity 3. ADME Principles in Small Molecule Drug Discovery and Development: An Industrial Perspective 4. Biotherapeutic ADME and PK/PD Principles 5. Principles of Pharmacodynamics and Toxicodynamics 6. Morphologic Manifestations of Toxic Cell Injury 7. The Role of Pathology in Evaluation of Reproductive, Developmental, and Juvenile Toxicity 8. Carcinogenesis: Mechanisms and Evaluation

Part 2 Methods in Toxicologic Pathology 9. Basic Approaches to Anatomic Toxicologic Pathology 10. Clinical Pathology in Nonclinical Toxicity Testing 11. Special Techniques in Toxicologic Pathology 12. Digital Pathology and Tissue Image Analysis 13. In Vivo Small Animal Imaging: A Comparison to Gross and Histopathologic Observations in Animal Models 14. Biomarkers: Discovery, Qualification and Application 15. Toxicogenomics: A Primer for Toxicologic Pathologists 16. Experimental Design and Statistical Analysis for Toxicologic Pathologists

Part 3 Animal and Alternative Models in Toxicologic Research 17. Animal Models in Toxicologic Research: Rodents 18. Animal Models in Toxicologic Research: Rabbit 19. Animal Models in Toxicologic Research: Dog 20. Animal Models in Toxicologic Research: Pig 21. Animal Models in Toxicologic Research: Nonhuman Primate 22. Animal Models in Toxicologic Research: Non-mammalian 23. Genetically Engineered Animal Models in Toxicologic Research 24. Alternative Models in Biomedical Research: In Silico, In Vitro, Ex Vivo, and Non-Traditional In Vivo Approaches

Part 4 Practice of Toxicologic Pathology 25. Nomenclature and Diagnostic Resources in Anatomic Toxicologic Pathology 26. Pathology Peer Review 27. Pathology and GLPs, Quality Control and Quality Assurance 28. Practices to Optimize Generation, Interpretation, And Reporting of Pathology Data from Toxicity Studies 29. Issues in Laboratory Animal Science that Impact Toxicologic Pathology