Handbook of Systems Biology: Concepts and Insights

ISBN-13: 9780123859440 / Angielski / Twarda / 2012 / 538 str.

Lynne Walhout Hinojosa

Opis

This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics.

• 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards
• Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines
• Includes the latest research developments in human and animal models to assist with translational research
• Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers

Recenzje

"Systems biology is a field concerned with the interactions of biomolecules, tissues, and organs amongst each other. This work is essentially an introductory textbook for this field as well as a reference for scientists working in it. Editors Walhout and Dekker are systems biologists, while Vidal is a geneticist. They bring together numerous contributors with backgrounds ranging from physics to various biological specialties." --Reference & Research Book News, December 2013

"This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work." --Doody.com, April 24, 2013

Spis treści

SECTION I: Component of biological systems 1. Proteomic analysis of cellular systems 2. The protein-coding transcriptome 3. ncRNAs and their targets

SECTION II: Network properties of biological systems 4. Probabilistic functional networks 5. Protein-protein inteactome networks 6. Gene regulatory networks 7. Phenotypic profiling networks 8. Genetic interaction networks 9. Chromatin networks 10. Drug-target networks 11. Graph theory properties of cellular networks

SECTION III: Dynamic and logical propoerties of biological systems 12. Boolean models of cellular networks 13. Bayesian approaches in understanding networks 14. Transcriptional network logic in development 15. Metabolic systems reconstruction 16. Evolution of biological networks 17. Systems understanding of the cell cycle 18. Quantitative design principles on molecular systems 19. Systems biology of signaling 20. Single cell systems dynamics 21. Spatial organization of cellular systems

SECTION IV: Systems and biology 22. Systems understanding of yeast biology 23. Systems understandingof c.elegans development 24. Biological systems in Arabidopsis 25. Biological rhythms in development and hemeostasis 26. System biology of stem cells 27. The brain connectome

SECTION V: MULTISCALE BIOLOGICAL SYSTEMS, HEALTH AND ECOLOGY 28. Systems medicine 29. Cancer systems biology 30. Infectious disease and the immune system 31. Network perturbations and disease states 32. Impact of personal genomics on systems biology 33. Social networks, human disease, and epidemics