Handbook of Pre-Clinical Continuous Intravenous Infusion

ISBN-13: 9780748408672 / Angielski / Twarda / 2000 / 344 str.

Guy Healing; David Smith

Opis

The techniques of continuous infusion are used for the administration of drugs during surgery, chemotherapy and in the treatment of a wide range of acute and chronic diseases. To enable these pharmaceuticals to be safely tested in humans, it is a regulatory and ethical requirement that their safety must first be assessed pre-clinically.

Recenzje

"…an excellent buy for anyone involved in drug development, risk assessment or within drug licensing agencies and in academic research. …This book represents a benchmark achievement for this technique …it will become the standard for many years to come"
British Toxicology Society Newsletter

Spis treści

Introduction. Femoral Cannulation Using the Jacket/Harness Model in the Rat. Femoral Cannulation Using the Tail Cuff Exteriorisation Method in the Rat. Tethering and the Implanted Button Model in the Rat. Multidose Infusion Toxicity Studies in the Rat. Reproductive Infusion Toxicity Studies in the Rat. Femoral Cannulation Using the Tail Cuff Model in the Mouse. Multidose Infusion Toxicity Studies in the Mouse. Jugular Cannulation and Efficacy Studies in the Mouse. Femoral Cannulation of the Rabbit for Reproductive Toxicity Studies. Jugular Cannulation of the Rabbit for Reproductive Toxicity Studies. Jugular Cannulation of the Dog. The Non-Ambulatory Model in Dog Multidose Infusion Toxicity Studies. The Ambulatory Model in Dog Multidose Infusion Toxicity Studies. Surgical Preparation of the Large Primate. Multidose Infusion Toxicity Studies in the Large Primate. Surgical Preparation and Multidose Infusion Toxicity Studies in the Marmoset. Surgical Preparation of the Mini-Pig. Multidose Infusion Toxicity Studies in the Mini-Pig. Reproductive Toxicity Studies in the Mini-Pig. Common Pathological Findings in Continuous Infusion. The Use of Mini-Osmotic Pumps in Continuous Infusion Studies. The Contribution of Vehicles, Rates of Administration and Volumes to Infusion Studies. Equipment for Continuous Intravenous Infusion.

NTI/Sales Copy

O autorze

Guy Healing, David Smith