From Basic Immunology to Immune-Mediated Demyelination

ISBN-13: 9788847021792 / Angielski / Miękka / 2012 / 315 str.

Gianvito Martino; Luciano Adorini

Opis

This book covers the immunological and clinical aspects of central and peripheral nervous system inflammatory diseases characterized by myelin damage. Leading scientists in the field have summarized in short reviews the state of the art of neuroimmunology, with particular emphasis on basic aspects of the regulation of immune responses during demyelinating disorders. The volume will be helpful to neuroimmunologists, but also to clinicians which will find a clear and concise understanding of the main features of neuroinflammatory disease.

Spis treści

Protective versus harmful responses and immune regulation Organization of the immune system antigen recongnition and autoimmunity Assembly and function of immunoglobulines during B cell development Immunological tolerance Pathogenetic mechanisms of autoimmunity Adhesion receptors involved in leukocyte functions The endothelium of the brain microvasculature and the organization of intercellular junction Chemokine and chemokine receptors The1/Th2 cytokine network Lymphocyte trafficking in the central nervous system Antigen presentation in the central nervous system Adhesion molecules and the blood-brain-barrier in multiple sclerosis Myelination steps in the central nervous system Genomic screen in multiple slerosis MHC and multiple sclerosis Cytokine genes in multiple sclerosis Non-myelin antigen autoreactivity in multiple sclerosis Myelin antigen autoreactivity in multiple sclerosis Inflammation and demyelination Magnetic resonance and blood-brain barrier dysfunction in multiple sclerosis Immunotherapies for multiple sclerosis Animal models of demyelination of the central nervous system MHC and non MHC genetics of rat EAE Genetic of hereditary neuropathies Animal models of demyelination in the PNS Immune-mediated neuropathies: diagnostic procedures Pathology of demyelination neuropathies Immunopathogenetic role of anti-neural antibodes in demyelinating dysimmune neuropathies