Evolution of antigen binding receptors

ISBN-13: 9783330326460 / Angielski / Miękka / 2017 / 108 str.

N B Thippeswamy

Opis

This book addresses issues related to the evolution of complex multigene families of antigen binding receptors that function in adaptive immunity. Both Ig and TCR genes have been defined in most of the major lineages of jawed vertebrates, including the cartilaginous fishes, which represent the most phylogenetically divergent jawed vertebrate group relative to the mammals. Ig genes in cartilaginous fish are encoded by multiple individual loci that each contain rearranging segmental elements and constant regions. In some loci, segmental elements are joined in the germline, i.e., they do not undergo genetic rearrangement. Other major differences in Ig gene organization and the mechanisms of somatic diversification have occurred throughout vertebrate evolution. As of yet, homologous forms of antigen binding receptors have not been identified in jawless vertebrates; however, acquisition of large amounts of structural data for the antigen binding receptors that are found in a variety of jawed vertebrates has defined shared characteristics that provide unique insight into distant origins of rearranging gene systems and their relationships to both adaptive and innate recognition processes.

O autorze

Dr. N. B. Thippeswamy received his master's degree from the department of Microbiology, Kuvempu University and Ph.D degree from the department of Biochemistry, Kuvempu University in the year 1996 and 2014, respectively. He has 14 years of teaching experience and 16 years of research experience in the field of Immunology and Microbiology.