Essentials of Toxic Chemical Risk: Science and Society

ISBN-13: 9780415248518 / Angielski / Twarda / 2010 / 212 str.

Penningroth Penningroth; Stephen Penningroth

Opis

A contribution to the ongoing debate about how to manage the growing risks of anthropogenic chemicals in the environment, Essentials of Toxic Chemical Risk weaves together coverage of the science that underlies toxic chemical risk assessment, the physiological and molecular bases of chemical toxicity, the process of assessing toxic chemical risk to human health and the environment, and the strategies employed in managing it. The book links toxic chemical risk to the real world of people and communities confronted with the vexing problem of how to deal with products that make their lives better but that also harbor a potential for harm. The book introduces the basics of toxicology from a risk assessment perspective, using a jargon-free, journalistic style that makes scientific concepts accessible to a wide audience without "dumbing down" the science. It covers the fate and transport of chemicals in the environment, dose-effect, animal toxicity testing, human epidemiology, the uptake, distribution, and elimination of toxic chemicals including first-order rate constants and calculations of body burdens, and the cellular basis of cancer and other diseases that can be caused by toxic chemicals. The book also introduces risk management and discusses the balance between precaution and socio-economic benefits, as embodied by the Toxic Substances Control Act, the Canadian Environmental Protection Act, and the European Union's innovative REACH directive (Registration, Evaluation, Authorization, and Restriction of chemicals). Putting equal emphasis on the twin issues of risk assessment and risk management, the author has carefully selected topics that shed light on risk management decisions and cover ecotoxicolocy and organismic toxicology. The book provides a thorough introduction to the science of toxicology and to the policy debates and scientific uncertainties that make risk management a work in progress.

Spis treści

Toxic Chemical Risk as Science and Social Discourse. Environmental Pathways of Toxic Chemicals. Dose-Effect: The Foundation of Toxicological Science. Human Populations at Risk. The Cornerstone of Risk Assessment: Toxicity Testing in Animals. The Body’s Defenses against Chemical Toxicity. Mechanisms of Chemical Disease. Human Health Risk Assessment. Ecological Risk Assessment. Managing Chemical Risk in North America and Europe. Index.