Epithelial Secretion of Water and Electrolytes

ISBN-13: 9783642750359 / Angielski / Miękka / 2011 / 379 str.

John A. Young; Patrick Y. D. Wong

Opis

This volume aims to give a comprehensive overview of the cellular mechanisms underlying the process of secretion in vertebrate, particularly mammalian, exocrine glands. The subject matter is divided into two sections. The first section deals with general aspects of secretion, including chapters on the roles of ion channels in secretion. Signal transduction is also covered, and several chapters deal with recently developed investigative techniques that offer promise as tools for the further investigation of exocrine secretory processes. The second section deals with secretion in a selection of exocrine organs: salivary glands, lacrimal glands, the pancreas, gastric mucosa, liver, epididymis, and vertebrate salt glands. A final chapter deals with cystic fibrosis, the common, fatal, inherited disease, which affects exocrine glands particularly severely.

Spis treści

A General Aspects of Secretion.- Epithelial Chloride Channels.- Cation Channels and Secretion.- Gap Junctions in Exocrine Glands.- Ion Channels in the Intracellular Organelles of Secretory Cells.- Changes in Membrane Capacitance in Exocrine Secretion.- The Coupling of Stimuli to the Secretion of Protein in Exocrine Glands.- Ion Transport in Mutant Cell Lines: Possibilities for Analysis.- Use of Nuclear Magnetic Resonance Spectroscopy in the Study of Exocrine Secretion.- Graded Modelling of Exocrine Secretion Using Network Thermodynamics.- B Secretion in Individual Tissues.- 1 Salivary Glands.- Role of Anion Transport in Secretion of Primary Saliva.- The Role of Transcellular Chloride Transport in Exocrine Secretion.- Bicarbonate Transport by Salivary Gland Acinar Cells.- Electrophysiology of Salivary Acinar Cells: Microelectrode Studies.- Physiology of Salivary Gland Exocytosis.- Non-Adrenergic, Non-Cholinergic Control of Salivary Gland Function.- 2 Lacrimal Glands.- Electrolyte Secretion by the Lacrimal Glands.- 3 Exocrine Pancreas.- Electrolyte Transport in Pancreatic Ducts.- The Role of Ion Channels in the Mechanism of Pancreatic Bicarbonate Secretion.- The Metabolic Basis of Secretion by the Exocrine Pancreas.- 4 Endocrine Pancreas.- Ion Channels in Insulin-Secreting Cells: Their Role in Stimulus-Secretion Coupling.- 5 Gastric Mucosa.- Electrophysiological Aspects of Gastric Ion Transport.- 6 Liver.- Hepatic Electrolyte Transport and Bile Formation.- 7 Epididymis.- Electrolyte and Fluid Transport in the Epididymis.- 8 Salt Glands.- Ultrastructure and X-Ray Microanalysis of Vertebrate Salt Glands.- 9 Cystic Fibrotic Epithelia.- Ion Transport Regulation in Cystic Fibrosis Epithelia.