Encyclopedia of Immunotoxicology

ISBN-13: 9783642545955 / Angielski / Twarda / 2015 / 983 str.

Hans-Werner Vohr

Opis

This work provides rapid access to focused information on topics of Immunotoxicology not only for scientists and those dealing with laboratory aspects but also for lecturers and advanced students. Over 200 contributing authors - including many of the world's top specialists - have contributed full essays on all relevant topics, supplemented by keyword definitions of related terms. Full essays are structured uniformly to provide reader-friendly information on all aspects of Immunotoxicology, including methods of testing and analysis, characteristics of substances, the regulatory environment and the relevance of these to humans.

Spis treści

AB0 Blood Group System.- Aging and the Immune System.- Animal Models for Respiratory Hypersensitivity.- Animal Models of Immunodeficiency.- Anti-Inflammatory (Nonsteroidal) Drugs.-

Antibodies, Antigenicity of.- Antibody-Dependent Cellular Cytotoxicity.- Antigen Presentation via MHC Class II Molecules.- Antigen-Presenting Cell (APC).- Antigen-Specific Cell Enrichment.- Antiglobulin (Coombs) Test.- Antinuclear Antibodies.- Apoptosis.- Assays for Antibody Production.-

Asthma.- Atopic Allergy.- Attenuated Organisms as Vaccines.- Autoantibodies, Tests for Autoantigens.- Autoimmune Disease, Animal Models.- Autoimmunity, Autoimmune Diseases.-

B Cell Maturation and Immunological Memory.- B Lymphocytes.- Biological drugs, immunosuppression and modulation.- Birth Defects, Immune Protection Against.- Blood Coagulation.- Bone Marrow and Hematopoiesis.- Brain-Immune Interactions.- Cancer and the Immune System.- Canine Immune System.- Carcinogenesis.- Cardiac Disease, Autoimmune

Cat immune system.- CD Markers.- Cell Adhesion Molecules.- Cell Separation Techniques.-

Cell-Mediated Lysis.- Chemical Structure and the Generation of an Allergic Reaction.- Chemokines.-

Chemotaxis of Neutrophils.- Chromium and the Immune System.- Chronic Beryllium Disease.-

Clinical consequence of immunosuppression.- Colony-Forming Unit Assay: Methods and Implications.- Complement and Allergy.- Complement Deficiencies.- Complement System.-

Contact Hypersensitivity.- Cyclosporin A.- Cytokine Assays.- Cytokine Genes and Immunotoxicology, Genetic variations.- Cytokine Inhibitors.- Cytokine Receptors.- Cytokines.- Cytotoxic T Lymphocytes.-

Cytotoxicity Assays.- Delayed-Type Hypersensitivity.- Dermatological Infections.- Developmental Immunotoxicology.- Diabetes and Diabetes Combined with Hypertension, Experimental Models for

Dioxins and the Immune System.- DNA Vaccines.- Drugs, Allergy to.- ELISPOT Assay.- Enzyme-Linked Immunospot Assay (ELISPOT).- Epidemiological Investigations.- Erythropoietin.- Exposure Route and Respiratory Hypersensitivity.- Fatty Acids and the Immune System.- Fish Immune System.-

Flow Cytometry Technique.- Food Allergy.- Germinal Center.- Glucocorticoids.- Graft-Versus-Host Reaction.- Granuloma.- Guinea Pig Assays for Sensitization Testing.- Hapten and Carrier Helper T Lymphocytes.- Hematopoietic Stem Cells.- Hemolytic Anemia, Autoimmune.- Hepatic Immune System.- Hepatitis, Autoimmune.- Histopathology of the Immune System, Enhanced Host Resistance Assays.- Human artificial lymph node (hALN).- Human microbiome.- Humanized Monoclonal Antibodies.- Humoral Immunity.- Hypergammaglobulinemia.- Hypersensitivity Reactions.-

Idiotype Network.- IgE-Mediated Allergies.- Immune Cells, Recruitment and Localization of

Immune Complexes and Complement Activation.- Immune Function Assessment for Risk Assessment in Drug and Registration (Industry, Agro-) Chemicals, Relevance of Immune Response.- Immunoassays.- Immunoglobulin. Subclasses and Functions.- Immunopathology.- Immunotoxic Agents into the Body, Entry of.- Immunotoxicological Evaluation of Therapeutic Cytokines.-

Immunotoxicology.- Immunotoxicology of Biotechnology-Derived Pharmaceuticals.- Immunotoxicology, in silico analyses.- Immunotoxicology, view of the future.- In vitro PFCA (MD cultures).- Inbred Strains.- Inflammatory Reactions, Acute Versus Chronic.- Interferon-γ

Interleukin-1β (IL-1β).- International Collaborative Studies on the Detection of Immunotoxicity.- Klebsiella, Infection and Immunity.- Knockout, Genetic.- Leukemia.-

Leukocyte Culture: Considerations for In Vitro Culture of T cells in Immunotoxicological Studies.-

Limiting Dilution Analysis.- LMW drugs, immunosuppression and modulation.- Local Lymph Node Assay.- Local Lymph Node Assay (IMDS), Modifications.- Lymph Nodes.- Lymph Transport and Lymphatic System.- Lymphocyte Proliferation.- Lymphocyte Transformation Test.- Lymphocytes

Lymphoma.- Macrophage Activation.- Mast Cells.- Maturation of the Immune Response.-

Memory, Immunological.- Metabolism, Role in Immunotoxicity.- Metals and Autoimmune Disease.-

MHC Class I Antigen Presentation.- Mitogen-Stimulated Lymphocyte Response.- Mixed Lymphocyte Reaction.- Molecular Mimicry.- .- Monoclonal Antibodies.- Mouse Ear Swelling Test.- Mucosa-Associated Lymphoid Tissue.- Natural Antibodies.- Natural Killer Cell Assay.- Natural Killer Cells

Neonatal Immune Response.- Neutrophil.- Nonhuman Primates, Immunotoxicity Assessment of (Bio)Pharmaceuticals in Nutrition and the Immune System.- Opsonization and Phagocytosis.-

Oral Mucositis and Immunotoxicology.- Pharmacokinetics and Pharmacodynamics of Therapeutic Monoclonal Antibodies.- Photoreactions.- Photoreactive Compounds.- Plaque Versus ELISA Assays. Evaluation of Humoral Immune Responses to T-Dependent Antigens.- Plaque-Forming Cell Assays.-

Polychlorinated Biphenyls and the Immune System.- Polyclonal Activators.- Polycyclic Aromatic Hydrocarbons and the Immune System.- Polymerase Chain Reaction.- Popliteal Lymph Node Assay.-

Popliteal Lymph Node Assay, Secondary Reaction.- Porcine Immune System.- Primate Immune System (Nonhuman) and Environmental Contaminants.- Prostaglandins.- Rabbit Immune System.-

REACH and Immunotoxicology.- Regulatory Environment.- Regulatory Guidance in Immunotoxicology.- Relative Risk.- Reporter Antigen Popliteal Lymph Node Assay.- Respiratory Infections.- Rheumatoid Arthritis and Related Autoimmune Diseases, Animal Models.- Rodent Immune System, Development of the.- Rodents, Inbred Strains.- <i>Salmonella</i>, Assessment of Infection Risk.- Septic Shock.- Serotonin.- Serum Sickness.- Signal Transduction During Lymphocyte Activation.- Skin, Contribution to Immunity.- Southern and Northern Blotting.- Spleen.- Statistics in Immunotoxicology.- Steroid Hormones and their Effect on the Immune System.- Streptococcus Infection and Immunity.- Stress and the Immune System.- Superantigens.- Suppressor Cells

Systemic Autoimmunity.- T Regulator Cells.- TDAR Update for NHP Immunotoxicity Studies

Tests for Autoimmunity.- TH17 Cells.- Three-Dimensional Human Skin, Epidermal Models and Organotypic Human and Murine Skin Explant Systems.- Thymus.- Thymus: A Mediator of T Cell Development and Potential Target of Toxicological Agents.- Tolerance.- Toxicogenomics, Microarray Technology.- Trace Metals and the Immune System.- Transforming Growth Factor β1; Control of T Cell Responses to Antigens.- Transgenic Animals.- Trypanosomes, Infection and Immunity.-

Tumor Necrosis Factor-α.- Tumor, Immune Response to.- Vaccines therapeutic.- Vanadium and the Immune System.- Viability, Cell.- Vitamins.- Western Blot Analysis.

 

O autorze

Dr. Vohr is working as "Senior Expert" for immunotoxicology with global responsibility for Bayer HealthCare AG, and is a member of various international expert councils for immunotoxicology and photoreactions.