Egfr-Directed Therapy in Lung Cancer

ISBN-13: 9781009342308 / Angielski / Miękka / 2023 / 75 str.

Balazs Halmos

Opis

This Element describes the pathophysiology and current and future management of EGFR-mutant non-small cell lung cancer.

Spis treści

1.Structural biology and mechanism of activation of EGFR; 2. EGFR-associated oncogenesis; 3. Tyrosine kinase inhibitors (TKIs) as targeted treatment for EGFR-mutant NSCLC; 4. EGFR-TKIs as adjuvant or neoadjuvant therapy; 5. EGFR-Exon 20 insertion mutations; 6. Resistance mechanisms and therapies in metastatic resistant EGFR-NSCLC; 7. Uncommon EGFR-activating mutations; 8. Immunotherapy in metastatic EGFR-mutant NSCLC; 9. Management of CNS disease and oligometastatic EGFR-mutant NSCLC; 10. ctDNA in EGFR-mutant NSCLC; 11. Guidelines and recommendations for EGFR-mutant NSCLC; References.