Drug Discovery and Development : Technology in Transition

ISBN-13: 9780702042997 / Angielski / Miękka / 2012 / 368 str.

Raymond G. Hill

Opis

Provides an introduction to the way the industry goes about the discovery and development of new drugs. This title provides an account from its origins in the mediaeval apothecaries' trade, and discusses the changing understanding of what we mean by disease, and summarizes case histories of the discovery and development of some important drugs.

Spis treści

Contents

SECTION 1

INTRODUCTION AND BACKGROUND

1. The development of the pharmaceutical industry

H P Rang

2. The nature of disease and the purpose of therapy

H P Rang, R G Hill

3. Therapeutic modalities

H P Rang, H LeVine, R G Hill

SECTION 2

DRUG DISCOVERY

4. The drug discovery process: general principles and some case histories

H P Rang, R G Hill

5. Choosing the project

H P Rang, R G Hill

6. Choosing the target

H P Rang, R G Hill

7. The role of information, bioinformatics and genomics

B Robson, R McBurney

8. High-throughput screening

D Cronk

9. The role of medicinal chemistry in the drug discovery process

P Beswick, A Naylor

10. DMPK optimization strategy in drug discovery

P G Ballard, P Brassil, K H Bui, H Dolgos, C Petersson, A Tunek, P J H Webborn

11. Pharmacology: its role in drug discovery

H P Rang

12. Biopharmaceuticals

H LeVine

13. Scaffolds: Small globular proteins as antibody substitutes

D Grabulovski, J Bertschinger

SECTION 3

DRUG DEVELOPMENT

14. Drug development: introduction

H P Rang, R G Hill

15. Assessing drug safety

H P Rang, R G Hill

16. Pharmaceutical developmentT Lundqvist, S Bredenberg

17. Clinical Development - Present and Future

C Keywood

18. Clinical imaging in drug development

P M Matthews

19. Intellectual property in drug discovery and development

P Grubb

20. Regulatory affairs

I Hägglöf, Å Holmgren

21. Marketing the drug

V L Lawton

SECTION 4

FACTS AND FIGURES

22. Drug discovery and development - facts and figures

H P Rang, R G Hill