Diseases of the Cardiac Pump

ISBN-13: 9783319126630 / Angielski / Twarda / 2015 / 631 str.

Marc Thiriet

Opis

Together, the volumes in this series present all of the data needed at various length scales for a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanism. Therefore, investigation of flows of blood and air in anatomical conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning in quantitative terms.The present volume focuses on macroscopic aspects of the cardiovascular and respiratory systems in pathological conditions, i.e., diseases of the cardiac pump, blood vessels, and airways, as well as their treatments. Only diseases that have a mechanical origin or are associated with mechanical disorders are covered. Local flow disturbances can trigger pathophysiological processes or, conversely, result from diseases of conduit walls or their environment. The ability to model these phenomena is essential to the development and manufacturing of medical devices, which incorporate a stage of numerical tests in addition to experimental procedures.

Recenzje

"This is a review of macroscopic aspects of diseases of the cardiac pump as well as treatments that could be potential targets for biomechanical studies. ... The intended audience includes researchers, practitioners, and students in the fields of medicine and cardiovascular disease who are interested in biomechanical and biomathematical aspects of cardiac diseases. ... It is strongly recommended for its intended audience." (Samit Bhatheja, Doody's Book Reviews, June, 2015)

Spis treści

Heart Pathologies.- Risk Factors.- Genetic Background.- Oxidative and Nitrative Stresses and Cardiac Diseases.- Congenital Heart Defects.- Maladaptive Myocardial Remodeling.- Cardiac Defficiency - Heart Failure.- Cardiomyopathies.- Conduction and Rhythm Disorders.- Valve Failure.- Aortic Valve Failure.- Myocardial Ischemia and Infarction.- Vascular Diseases.- Biochemical and Genetic Framework.- Cardiovascular Markers.- Endothelium Dysfunction.- Obstructive Sleep Hypopnea-Apnea Syndrome.- Hypertension Metabolic Syndrome.- Toxicant Exposure.- Arterial Wall Remodeling.- Vascular Calcification.- Aortic Coarctation.- Acute Aortic Syndrome.- Aortic Dissection.- Thrombosis.- Aneurysms.- Atheroma.- Arteriosclerosis.- Chronic Venous Insufficiency.- Pulmonary Embolism.- Respiratory Diseases.- Respiratory Infections.- Respiratory Allergy.- Bronchial Hyperresponsiveness Major Diagnosis Techniques.- Obstructive Disorders.- Pulmonary Cysts or Bullae.- Cystic Fibrosis or Mucovicidosis.- Primary Ciliary Dyskinesia.- Dual Defiiencies.- Restrictive Disorders.- Sleep Disordered Breathing _ Obstru
tive Sleep Apnea and Hypopnea Hyperoxia - Oxygen Toxicity Syndrome.- Acute Lung Injury - Acute Respiratory Distress Syndrome.- Pulmonary Vascular Diseases.- Therapy of Respiratory Diseases.- Treatments of Cardiovascular Diseases.- Medical and Surgical Robotics.- Surgery
Electrical Stimulation.- Endovascular Therapy.- Stem Cell-Based Regenerative Therapy.- Mechanophore-Linked Materials.- Nanotechnology-Based Therapy.- Medical and Surgical Simulators.- Conclusion.- References.- List of Currently Used Prefixes and Suffixes.- List of Aliases and Primary Symbols.- Complementary Lists of Notations.- Index.