Current Concepts in Drug Metabolism and Toxicology: Volume 63

ISBN-13: 9780123983398 / Angielski / Twarda / 2012 / 304 str.

Gabrielle Hawksworth

Opis

This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

• Explores the current concepts in drug metabolism and toxicology
• Chapters cover such areas as the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity
• An essential resource for pharmacologists, immunologists and biochemists alike

Spis treści

1. Membrane Transporters in Drug Development
2. The Keap1-Nrf2 Cell Defence Pathway - A Promising Therapeutic Target?
3. Animal Models of Idiosyncratic Drug Reactions
4. Genetic Polymorphisms Affecting Drug Metabolism: Recent Advances and Clinical Aspects
5. Arylamine N-Acetyltransferases - from Drug Metabolism and Pharmacogenetics to Identification of Novel Targets for Pharmacological Intervention
6. Human Pluripotent Stem Cells for Modelling Toxicity
7. Disposition of Biologics