Concepts and Principles of Pharmacology: 100 Years of the Handbook of Experimental Pharmacology

ISBN-13: 9783030353612 / Angielski / Twarda / 2020 / 466 str.

James E. Barrett; Clive Page; Martin C. Michel

Spis treści

Part 1. A Century of Advances in Pharmacology.- 1. Perspectives of Pharmacology Over the Past 100 years.- 2. Emergent concepts of receptor pharmacology.- 3. The Evolving Landscape of Cancer Therapeutics.- 4. Monoclonal Antibodies: Past, Present and Future.- 5. 100 years of Drug Delivery to the Lungs.- 6. Exploiting the Diversity of Ion Channels:  Ion channel Pharmacology for Pain modulation.- 7. Exploiting the Diversity of Ion Channels:  Modulation of Ion Channels for Therapeutic Indications.- Part 2. Recent developments and enabling technologies in pharmacology.- 8. Genetically Encoded Fluorescent Calcium and Voltage Indicators.- 9. Mechanistic Image-Based Modeling: Concepts and Applications of Image-Based Modeling.- 10. Pharmacometabonomics: The Prediction of Drug Effects Using Metabolic Profiling.- 11. The Microbiome and its Potential for Pharmacology.- 12. Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology.- Part 3. The future of pharmacology.- 13. The future of clinical trial design: The Transition from Hard Endpoints to Value-Based Endpoings.- 14. Placebos and the Placebo Effect in Drug Trials.- 15. Pharmacoepidemiology.- 16. Why are new drugs expensive and how can they stay affordable?