Colorectal Cancer: From Pathogenesis to Prevention?

ISBN-13: 9783642859328 / Angielski / Miękka / 2012 / 391 str.

Helmut K. Seitz; Ulrich A. Simanowski; Nicholas A. Wright

Opis

The past 20 years have seen a surge of research into colorectal cancer, which is a reflection of the need to improve our methods of treating patients suffering from this increasingly common form of cancer. Greater knowledge of the basic mechanisms involved in colorectal carcinogenesis is an essential prerequisite to improvements in cancer prevention. In this volume the editors have brought together an impressive list of experts to cover the epidemiology, pathophysiology, morphology and basis for new diagnostic and therapeutic approaches to early detection and prevention. This broad scientific approach provides the reader with up-to-date review of our current state of knowl edge of colorectal carcinogenesis and indicates how this information can be used to generate more research and create new opportunities for diagnosis and treatment. This is a book of knowledge and ideas, some of them still at the stage of theoretical interest, but others with practical potential for the care of patients. I recommend it to those who have a research interest in colorectal carcinogenesis, as well as to readers who wish to know just how far medical scientists have progressed in their efforts to achieve the ideal of cancer prevention."

Spis treści

Epidemiology.- Geographic Epidemiology of Colorectal Cancer: The Role of Dietary Fat.- Genetic Predisposition to Colorectal Cancer.- Acquired Conditions of Increased Risk of Colorectal Cancer.- Inflammatory Bowel Disease and Colorectal Cancer.- Biomarkers in the Identification of High-Risk Groups.- Dietary Factors in the Pathophysiology of Colorectal Cancer.- Dietary Fat and Colorectal Cancer: Experimental Evidence for Tumor Promotion.- Cholesterol, Neutral Sterols and Colorectal Cancer.- The Role of Bile Acids in Colorectal Carcinogenesis.- Dietary Fibers, Fiber-Containing Foods, and Colon Cancer Risk.- Colorectal Bacteria in Colorectal Carcinogenesis.- Ethanol and Colorectal Carcinogenesis.- Pathophysiologic Mechanisms in Colorectal Carcinogenesis.- Environmental and Dietary Carcinogens Possibly Related to Colorectal Cancer.- Experimental Models of Colorectal Carcinogenesis.- Colonic Microsomal Enzymes and Their Role in Colorectal Carcinogenesis.- Mucosal Cellular Regeneration in Colorectal Carcinogenesis.- The Control of Cell Proliferation in Colonic Epithelium.- Arachidonic Acid Metabolism and Colorectal Cancer.- Biochemical Changes in Colorectal Carcinogenesis.- Inhibitors of Colorectal Carcinogenesis: Experimental and Therapeutic Aspects.- Oncogenes in Colorectal Cancer.- Morphology of Colorectal Cancer.- Histogenesis of Colorectal Carcinoma.- Cell Differentiation in Colorectal Carcinoma.- Attempts for Diagnostic and Therapeutic Approaches.- Immunoassay for Fecal Occult Blood and Early Detection of Colorectal Cancer.- Experimental Models to Study New Chemotherapeutic Agents in Colorectal Cancer.- Recommendation.- Dietary Prevention of Colorectal Cancer.