Circulating Tumor Cells in Breast Cancer Metastatic Disease

ISBN-13: 9783030358075 / Angielski / Miękka / 2021 / 167 str.

Roberto Pi?eiro

Spis treści

Preface Chapter 1.

Introduction – Biology of Breast Cancer Metastasis and Importance of the Analysis of CTCs

Chapter 2.

Epithelial-Mesenchymal Plasticity in Circulating Tumor Cells, the Precursors of Metastasis

Chapter 3.

Disseminated Tumor Cells and Dormancy in Breast Cancer Progression

Chapter 4.

Methodology for the Isolation and Analysis of CTCs

Chapter 5. Advances in the Characterization of Circulating Tumor Cells in Metastatic Breast Cancer: Single Cell Analyses and Interactions, and Patient-derived Models for Drug Testing

Chapter 6. Circulating Tumor Cells (CTCs) Heterogeneity in Metastatic Breast Cancer: Different Approaches for Different Needs

Chapter 7.

Relevance of CTC Clusters in Breast Cancer Metastasis

Chapter 8.

Epigenetics of Circulating Tumor Cells in Breast Cancer

Chapter 9.

Circulating Tumor Cells: Applications for Early Breast Cancer

Chapter 10.

Clinical Relevance and Therapeutic Application of CTCs in Advanced Breast Cancer

O autorze

Roberto Piñeiro completed his doctoral studies on the biology and metabolism of cardiomyocytes in 2005, in the Department of Medicine at the University of Santiago de Compostela. In 2007 he joined the Phosphoinositide group for his post-doctoral in the Blizard Institute, Queen Mary University of London, where he studied the role of the GPR55 receptor and its ligand, lysophosphatidyl inositol (LPI) on cell proliferation in prostate and ovarian cancer.

Then in 2011 he was incorporated into the Cell Signalling group of Barts Cancer Institute, Queen Mary University of London, currently located at the UCL Cancer Institute, University College London. In this laboratory, Roberto worked studying the role of Class I PI3K in cell signalling in cancer and the tumour micro environment using “knock-in” mice and cellular models.

He is currently Head of the Cancer Modelling Line of the Roche-Chus Joint Unit

Blurb

This book compiles the latest research and key findings about the role of circulating tumor cells (CTCs) in Breast Cancer progression, both from the research and clinical standpoint. Based on latest advancements, the content of the book is set out to provide a clear overview about the biology and use of CTCs as a tool for the monitoring and management of breast cancer patients.

This work covers basic concepts about the process of metastasis, the biology of CTCs and their potential applications as a biomarker in breast cancer. It will enable readers to delve into the process of epithelial-mesenchymal plasticity (EMP), mechanisms and clinical implications of tumor cell dormancy and minimal residual disease, and into the phenotypical and molecular heterogeneity of CTCs and CTC clusters, including the epigenetic characterization of CTCs. Readers will find out about the key technologies used for the isolation of CTCs as well as the latest advances towards the characterization of CTCs, involving single cell analyses and patient-derived models. It will discuss the evidences about the use of CTCs as a tool to monitor breast cancer progression and therapy response, as well as to unravel mechanisms of resistance to therapy and to identify new therapeutic targets favoring the development of novel anticancer drugs. Lastly, it will discuss ongoing clinical trials and try to foresee the future of CTCs in terms of clinical application and implementation in the clinical routine.

The topic of this book is particularly relevant for cancer researchers and oncologist with an interest in the field, looking to refresh or to broaden their knowledge and understanding about the use of CTCs as a diagnostic biomarker in breast cancer.