Chiral Separations: Methods and Protocols

ISBN-13: 9781493994373 / Angielski / Twarda / 2019 / 487 str.

Gerhard K. E. Scriba

Recenzje

"The book is aimed at investigators in any discipline working in the field of chirality. It will be of special interest to anyone who has a need to separate chiral molecules. ... Detailed protocols are provided for the systems covered in the book that will make it easier for investigators wishing to replicate one of these procedures." (Thomas J. Wenzel, Analytical and Bioanalytical Chemistry, Vol. 411, 2019)

Spis treści

1. Recognition Mechanisms of Chiral Selectors: An Overview

            Gerhard K.E. Scriba

 

2. Enantioseparation by Thin Layer Chromatography

            Rituraj Dubey and Ravi Bhushan

 

3. Enantioseparations by Gas Chromatography Using Porous Organic Cages as Stationary Phase

            Sheng-Ming Xie, Jun-Hui Zhang, and Li-Ming Yuan

 

4. Chiral Metabolomics Using Triazine-Based Chiral Labeling Reagents by UPLC-ESI-MS/MS

            Toshimasa Toyo'oka

 

5. Chiral Mobile Phase Additives in HPLC Enantioseparations

            Lushan Yu, Shengjia Wang, and Su Zeng

 

6. Polysaccharide-Based Chiral Stationary Phases for Enantioseparations by High Performance Liquid Chromatography: An Overview

            Bezhan Chankvetadze

 

7. HPLC Enantioseparations with Polysaccharide-Based Chiral Stationary Phases in HILIC Conditions

            Roberto Cirilli

 

8. Functional Cyclodextrin-Clicked Chiral Stationary Phases for Versatile Enantioseparations by HPLC

            Jie Zhou, Jian Tang, and Weihua Tang

 

9. HPLC Enantioseparation on Cyclodextrin-Based Chiral Stationary Phases

            Xiaoxuan Li and Yong Wang

 

10. Hybrid Organic-Inorganic Materials Containing a Nanocellulose Derivative as Chiral Selector

            Liang Zhao, Hui Li, Shuqing Dong, and Yanping Shi

 

11. Cyclofructans as Chiral Selectors: An Overview

            Garrett Hellinghausen and Daniel W. Armstrong

 

12. High-Performance Liquid Chromatography Enantioseparations Using Macrocyclic Glycopeptide-Based Chiral Stationary Phases: An Overview

            István Ilisz, Tímea Orosz, and Antal Péter

 

13. Application of Sub-2 Micron Particles Silica Hydride Derivatized with Vancomycin for Chiral Separations by Nano-Liquid Chromatography

            Chiara Fanali and Salvatore Fanali

 

14. Cinchona Alkaloid-Based Zwitterionic Chiral Stationary Phases Applied for Liquid Chromatographic Enantiomer Separations: An Overview

            István Ilisz, Attila Bajtai, Antal Péter, and Wolfgang Lindner

 

15. Enantioseparations by High Performance Liquid Chromatography Based on Chiral Ligand-Exchange

            Federica Ianni, Lucia Pucciarini, Andrea Carotti, Roccaldo Sardella, and Benedetto Natalini

 

16. Applications of Chiral Supercritical Fluid Chromatography

            Emmanuelle Lipka

 

17. Chiral Separations by Countercurrent Chromatography

            Sheng-Qiang Tong

 

18. Cyclodextrins as Chiral Selectors in Capillary Electrophoresis Enantioseparations

            Gerhard K.E. Scriba and Pavel Jáč

 

19. Application of Dual Cyclodextrin-Systems in Capillary Electrophoresis Enantioseparations

            Anne-Catherine Servais and Marianne Fillet

 

20. Enantioseparation by Capillary Electrophoresis Using Cyclodextrins in an Amino Acid-Based Ionic Liquid Running Buffer

            Joachim Wahl and Ulrike Holzgrabe

 

21. Enantioseparations in Nonaqueous Capillary Electrophoresis Using Charged Cyclodextrins

            Anne-Catherine Servais and Marianne Fillet

 

22. Chiral Separation by NACE Using Polyol Derivative–Boric Acid Complexes

            Lijuan Wang, Xu Hou, Fan Zhang, Ying Liu, Yimeng Ren, and Hongyuan Yan

 

23. Chiral Capillary Electrophoresis-Mass Spectrometry

            María Castro-Puyana and María Luisa Marina

 

24. Enantioseparation of Selected Imidazole Drugs Using Dual Cyclodextrin-Modified Micellar Electrokinetic Chromatography

            Wan Aini Wan Ibrahim, Siti Munirah Abd Wahib, Dadan Hermawan, and Mohd Marsin Sanagi

 

25. Carbohydrate-Based Polymeric Surfactants for Chiral Micellar Electrokinetic Chromatography (CMEKC) Coupled to Mass Spectrometry

            Vijay Patel and Shahab A. Shamsi

 

26. Application of a (18-Crown-6)-2,3,11,12-Tetracarboxylic Acid-Based Chiral Stationary Phase in Capillary Electrochromatography

            Wonjae Lee, Kyung Tae Kim, and Jong Seong Kang

 

27. Experimental Design Methodologies for the Optimization of Chiral Separations: An Overview

            Luiz Carlos Klein-Júnior, Debby Mangelings, and Yvan Vander Heyden

Blurb

This detailed book focuses on analytical separations by chromatographic and electrophoretic techniques, providing some overview along with numerous practically-oriented applications of the most important analytical techniques in chiral separation sciences. While some compounds may only be enantioseparated with one technique based on the physico-chemical properties, often the analyst can choose between two or more analytical techniques for a given analyte, which requires knowledge of the strengths and weaknesses of each technique in order to select the most appropriate method for the given problem. This collection binds that knowledge in one volume. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and practical, Chiral Separations: Methods and Protocols, Third Edition serves as a helpful guide for analytical chemists working on stereochemical problems in the fields of pharmacy, chemistry, biochemistry, food chemistry, molecular biology, forensics, environmental sciences, or cosmetics in academia, government, or industry.