Chemistry and Biochemistry of B12

ISBN-13: 9780471253907 / Angielski / Twarda / 1999 / 944 str.

Ruma Banerjee; Ruma Banerjee

Opis

This work examines all the major new active areas of research in chemistry, including the structural chemistry of B12 and structural biology of B12-dependent enzymes, free radical-mediated reaction mechanisms, biosynthesis, and cloning. It discusses biochemical and biological aspects, including the role of B12 in nutrition and disease, B12 transport, biosynthesis and gene regulation, and enzymology.

Spis treści

CHEMISTRY OF B—12.

B—12 History (H. Hogenkamp).

X–ray Crystallography of B—12 (B. Kräutler & C. Kratky).

X–Ray Absorption Spectorscopy of B—12: Structural Changes of Intermediate States (M. Chance).

Electronic Structure and Spectra of B—12: From Trans Effects to Protein Conformation I (J. Pratt).

Electronic Structure and Spectra of B—12: From Trans Effects to Protein Conformation II (J. Pratt).

EPR Spectroscopy of B—12–Dependent Enzymes (G. Gerfen).

NMR Spectroscopy of B—12 (K. Brown).

Vibrational Spectroscopy of B—12 and Related Compounds (L. Marzilli & S. Hirota).

Magnetic Field Dependence of Cobalamin Photochemistry and Enzymes (C. Grissom).

Stereospecificity of the Coenzyme B—12 Catalyzed Rearrangements and the Role of Negative Catalysis (J. Retey).

Modeling the Structure of Cobalt Corrins by Molecular Mechanics and Molecular Dynamics Methods (H. Marques).

B—12 Electrochemistry and Organometallic Electrochemical Synthesis (B. Kräutler).

BIOCHEMISTRY AND BIOLOGY OF B—12.

B—12 and Nutrition (S. Stabler).

Inborn Errors of Cobalamin Metabolism (D. Rosenblatt & W. Fenton).

Diagnostic and Therapeutic Analogs of Cobalamin (H. Hogenkamp, et al.).

Intrinsic Factor and Haptocorrin and Their Receptors (D. Alpers & G. Russell–Jones).

Transcobalamin II (S. Rothenberg, et al.).

Mammalian Receptors of Vitamin B—12–Binding Proteins (S. Moestrup & P. Verroust).

Cobalamin Transport in Bacteria (C. Bradbeer).

Biosynthesis of B—12 in the Aerobic Organism Pseudomonas denitrificans (A. Battersby & F. Leeper).

B—12 Biosynthesis: The Anaerobic Pathway (A. Scott, et al.).

Biosynthesis of the 5–6 Dimethylbenzimidazole Moiety of Cobalamin and of the Other Bases Found in Natural Corrinoids (P. Renz).

Regulation of Adenosylcobalamin Biosynthesis in Salmonella typhimurium (J. Semerena).

X–ray Crystallography of B—12 Enzymes: Methylmalonyl–CoA Mutase and Methionine Synthase (M. Ludwig & P. Evans).

The Acetogenic Corriniod Proteins (S. Ragsdale).

The Role of Corrinoids in Methanogenesis (K. Sauer & R. Thauer).

Methionine Synthase (R. Matthews).

Methylmalonyl–CoA Mutase (R. Banerjee & S. Chowdhury).

Ribonucleotide Reductases (M. Fontecave & E. Mulliez).

Glutamate Mutase and 2–Methyleneglutarate Mutase (W. Buckel, et al.).

Diol Dehydrase and Glycerol Dehydrase (T. Toraya).

Ethanolamine Ammonia–Lyase (V. Bandarian & G. Reed).

Anomutases (P. Frey).

Isobutyryl–CoA Mutase (K. Zerbe–Burkhardt, et al.).

Reductive Dehalogenases (G. Wohlfarth & G. Diekert).

Blurb

A Definitive New Reference for the Latest Advances in B—12 Chemistry and Biochemistry Over the past decade, the field of B—12 research has been revolutionized by such major breakthroughs as the unraveling of the entire biosynthetic pathway for this important vitamin. This comprehensive compendium surveys the wealth of information that has accumulated, covering in one volume virtually all aspects of the field–from physical and inorganic chemistry to enzymology, microbiology, medicine, and diagnostic and therapeutic applications. Edited by Dr. Ruma Banerjee, a highly respected and active member of the B—12 community, this work provides B—12 researchers with a dependable and up–to–date reference on the subject. Leading authorities from five continents explore such new areas as the structural biology of B—12–dependent enzymes, free–radical–mediated reaction mechanisms, biosynthesis, and much more. The role of B—12 in nutrition and disease, and B—12 transport, are also thoroughly examined. Complete with color illustrations and extensive references, Chemistry and Biochemistry of B—12 is a one–of–a–kind resource for biochemists, biophysicists, spectroscopists, microbiologists, molecular biologists, and anyone with an interest in "nature′s most beautiful cofactor."