"This is a contemporary summary and review of the diagnostic parameters, biological processes, and treatment approaches for chronic lung transplant rejection. ... this book provides worthwhile and useful resources for trainees, practitioners, and researchers in lung transplantation. Pulmonary specialists and general practitioners who refer or care for transplant recipients also will find this book helpful. ... This is an up-to-date and comprehensive, in-depth, contemporary review of the complex factors that lead to chronic rejection following lung transplantation." (Derek E. Byers, Doody's Book Reviews, October, 2013)
1. Bronchiolitis Obliterans Syndrome and Chronic Lung Allograft Dysfunction: Evolving Concepts and Nomenclature
Keith C. Meyer and Allan R. Glanville
2. Airway Pathology in Lung Transplants
Amir Lagstein and Jeffrey Myers
3. Non-Bronchiolitis Obliterans Syndrome Forms of Chronic Lung Allograft Dysfunction
Gregory I. Snell,Bronwyn J. Levvey, Glen P. Westall
4. The Role of Thoracic Imaging in the Diagnosis of BOS and Related Disorders
Jeffrey P. Kanne
5. Making a Confident Diagnosis of Obliterative Bronchiolitis
A. Whitney Brown and Steven D. Nathan
6. The Role of Alloimmune T-Cell Responses in Obliterative Bronchiolitis
Tereza Martinu
7. Antibody-Mediated Rejection and the Bronchiolitis Obliterans Syndrome
Henry W. Ainge-Allen and Allan R. Glanville
8. Innate Immune Responses and Bronchiolitis Obliterans Syndrome
Jamie L. Todd and Scott M. Palmer
9. Mechanisms of Fibrogenesis in Post-Transplant Bronchiolitis Obliterans
Anish Wadhwa and Vibha N. Lama
10. The Role of Autoimmunity in the Pathogenesis of Obliterative Bronchiolitis
Rudolf K. Braun, Keith C. Meyer, and William J. Burlingham
11. The Role of Infections in BOS
Robin K. Avery
12. Gastroesophageal Reflux and Aspiration in Chronic Lung Allograft Dysfunction and Bronchiolitis Obliterans Syndrome: Detection and Treatment
Frank D’Ovidio and Beatrice Aramini
13. Bronchiolitis Obliterans Syndrome in Children
Paul D. Robinson and Paul Aurora
14. Immunosuppression for the Prevention and Treatment of BOS
Sangeeta M. Bhorade
15. Macrolides for the Prevention and Treatment of BOS
Robin Vos, Stijn E. Verleden, David Ruttens, Bart M. Vanaudenaerde,
and Geert M. Verleden
16. Other Treatments for Bronchiolitis Obliterans Syndrome
Ramsey Hachem
Bronchiolitis Obliterans Syndrome in Lung Transplantation presents the most current and up-to-date evidence regarding the diagnosis and management of BOS. In-depth chaptersprovide readers with a comprehensive understanding of the definition and changing perceptions of the nature of BOS as a clinical and pathologic entity, immune and non-immune mechanisms that have been identified as risk factors for the development of BOS, and interventions that may prove to be clinically useful for the prevention or treatment of BOS. In addition to outlining the current state of knowledge, each chapter provides the reader with the most current and ongoing research in the field as well as identifies areas where future research is needed. Written by an international group of expert authors, Bronchiolitis Obliterans Syndrome in Lung Transplantation is an important new text, that is essential reading for pulmonologists, primary care practitioners, respiratory care practitioners and clinical researchers.