Biomaterials Science and Implants: Status, Challenges and Recommendations

ISBN-13: 9789811569203 / Angielski / Miękka / 2021 / 228 str.

Bikramjit Basu

Opis

Biomaterials as a research theme is highly socially relevant with impactful applications inhuman healthcare. In this context, this book provides a state-of-the-art perspective onbiomaterials research in India and globally. It presents a sketch of the Indian landscapeagainst the backdrop of the international developments in biomaterials research.Furthermore, this book presents highlights from major global institutes of importance,and challenges and recommendations for bringing inventions from the bench to thebedside. It also presents valuable information to those interested in existing issuespertaining to developing the biomaterials research ecosystem in developing countries.The contents also serve to inspire and educate young researchers and students to take upresearch challenges in the areas of biomaterials, biomedical implants, and regenerativemedicine. With key recommendations for developing frontier research and policy, italso speaks to science administrators, policymakers, industry experts, and entrepreneurs onhelping shape the future of biomaterials research and development.

Spis treści

Table of Contents

Foreword by M.S. Valiathan

Foreword by K. Vijay Raghavan

Preface

 

1. Crossing the Boundaries

1.1 Biomaterials Bloom

1.2 The New Science

1.2.1 The Key Elements

1.2.2 Defining Biocompatibility

1.2.3 Structural Concepts

1.3 International and National Markets

1.4 Biomaterials in Human Healthcare

1.4.1 Musculoskeletal Surgery and Orthopedics

1.4.2 Neurosurgical Treatment

1.4.3 Urological Treatment

1.5 India’s Healthcare Initiatives and Translational Research Facilitation

1.5.1 Kalam Institute of Health Technology and the Andhra Pradesh Med Tech Zone

1.5.2 Niti Aayog and the National Health Stack

1.5.3 IKP Trust

1.6 Education and Human Resources

1.6.1 Bioengineering Curriculum

1.6.2 Medical Education and Research in India

1.7 Funding Status and Opportunity

1.7.1 National Schemes

1.7.1.1 Ministry of Science and Technology Funding

1.7.1.2 Biotechnology-focused funding

1.7.1.3 Recent Funding Schemes on Societally Relevant Areas

1.7.2 International Status

1.8 The Tailpiece

 

2. Scientists at Work

2.1 At the tipping point

2.2 All about joints: Hips, knees and spines

2.3 Bones and teeth

2.4 Cartilage, bone, cardiac and skin tissue engineering

2.5 Eyes and nerves

2.6 Antibacterial strategies

2.7 Regenerative Engineering

2.8 3D (Bio) printing biomaterials, tissues and organs

2.9 National Institutes of Importance and Centers of Excellence

2.9.1 Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum

2.9.2 School of International Biodesign, All India Institute of Medical Sciences, New Delhi

2.9.3 BETiC (Biomedical Engineering and Technology Incubation Centre), at IIT Bombay

2.9.4 Multi-institutional international research programs

2.10 Nota bene

2.11 A path ahead

 

3. International Status

3.1 Biomaterials Research Consortia of Global Importance 2

3.1.1 Prometheus Group, KU Leuven, Belgium

3.1.2 McGowan Institute for Regenerative Medicine, University of Pittsburgh

3.1.3 “Cúram - Centre for Research in Medical Devices”, National University of Ireland Galway

3.1.4 Wyss Institute at Harvard University, USA

3.1.5 Centre for Translational Bone, Joint and Soft Tissue Research at TU Dresden, Germany

3.1.6 Istituto di Scienza e Tecnologia dei Materiali Ceramici (ISTEC), Italy

3.1.7 3B’s Research Group, University of Minho, Portugal

3.1.8 National Institute of Standards & Technology (NIST), Gaithersburg, MD, USA

3.1.9 Wake Forest Institute for Regenerative Medicine, Winston-Salem North Carolina, USA

3.2 Multi-institutional research initiatives and training centers

3.2.1 Henry Royce Institute, UK

3.2.2 MatSan, France

3.2.3 Materials Assembly and Design Excellence in South Carolina (MADE in SC), Clemson University

3.2.4 “MD3: a new consortium for Materials Discovery, Development and Deployment”, Georgia Institute of Technology, USA

3.2.5 ARC Training center for Innovative Bioengineering, Australia

3.3 Closure

 

4. A Challenging Frontier

4.1 Challenge 1: Strengthening basic research in the quest for Next-Gen biomaterials

4.2 Challenge 2: Building translational research for human health

4.3 Challenge 3: Nourishing industry collaborations, incubators and start-ups

4.4 Challenge 4: Accelerating regulatory approval

4.5 Challenge 5: Medical education and the clinical research ecosystem

4.6 Challenge 6: Harnessing the benefits of biomaterials for the country

 

5. Benchside to Bedside: Recommendations for making biomedical devices and implants a national priority

5.1 Prelude

5.1.1 The Translational Gap

5.1.2 Science at the Local

5.1.3 Regulatory Impasse

5.1.4 Steering Science and Technology

5.1.5 The Power of Six

 

5.2 Priority Recommendations for Fostering Innovation and Growth of Biomedical Devices and Implants

5.2.1 Strategies to introduce appropriate regulations, foster capacities, facilities, infrastructure and capabilities to accelerate the regulatory approval processes

5.2.2 Strategies to strengthen basic research in biomaterials sciences for accelerated innovation of next generation biomaterials

5.2.3 Strategies to build up clinical, context-driven, translational research toward treatment of human diseases

5.2.4 Strategies to nourish industry collaborations and capabilities, grow and sustain incubators and start-ups

5.2.5 Strategies to revamp medical education and the clinical research ecosystem, to train and collaborate with clinicians of the future

5.2.6 Strategies to focus and align national policies and action plans to harness the benefits of biomaterials for the country 

 

6. Closure

References

Additional Reading

Appendix

Acknowledgements

O autorze

Bikramjit Basu is currently a Professor at the Materials Research Center and holds Associate Faculty position at Center for Biosystems Science and Engineering, Indian Institute of Science (IISc), Bengaluru. He is appointed as Visiting Professor at University of Manchester, UK (2018-23) and at the European Centre for Functional and Surface Functionalized Glass, Trenčín, Slovakia (2020-21). Bikramjit’s current research integrates biomaterials science and bioengineering approaches to address human healthcare challenges. Prof. Basu’s contributions in engineering sciences have been nationally and globally recognised. He received India’s most prestigious science and technology award, Shanti Swarup Bhatnagar Prize in 2013 for contributions to Biomaterials Science. A Chartered Engineer of the UK, he is an elected Fellow of the International Academy of Medical & Biological Engineering (2020), International Union of Societies for Biomaterials Science and Engineering (2020), Indian A^ 10,700 and H-index: 55). He has directed two large multi-institutional Indo-US and Indo-UK Biomaterials centers. Currently, he is the Lead Principal Investigator of the Translational Center of Excellence on biomaterials for orthopedic and dental applications, comprising of a national consortium of 43researchersfrom 8academic and medical institutes of India.