Biochemical Roles of Eukaryotic Cell Surface Macromolecules: 2011 Iscsm Proceedings

ISBN-13: 9781461433804 / Angielski / Twarda / 2012 / 340 str.

Perumana R. Sudhakaran; Avadhesha Surolia

Opis

Cell surface molecules are critically important in regulating cell structure and function. Recent advances on the functional role of cell surface molecules, particularly glycoconjugates are presented in this book. Comprising of 22 chapters from the 2011 International Symposium on Biochemical Roles of Eukaryotic Cell Surface Macromolecules, it covers topics on the analysis of glycome, biophysical approaches to study cell surface molecules, glycoconjugate metabolism and its dysregulation, and molecular mechanisms involved in cell-cell and cell-matrix interaction.

Spis treści

Preface

 

Chapter 1. Glycomics: An overview of the complex glycocode

 

Chapter 2. Structural Glycomic Approaches to Molecular Recognition Events on Cell Surfaces

 

Chapter 3. Chondroitin sulfate E-type structure at tumor cell surface is involved in experimental metastasis

 

Chapter 4. Chondroitin sulfate-specific novel hydrolase in human

 

Chapter 5. Identification of endothelial cell surface carbohydrate-binding receptors by carbohydrate ligand mimicry peptides.

 

Chapter 6. Lysosomal enzyme sorting receptors – Where did they first appear in the animal kingdom?

 

Chapter 7. Endoplasmic reticulum targeted Bcl‐2 inhibitable mitochondrial fragmentation initiates ER stress induced cell death

 

Chapter 8. Interactions between Caveolin-1and Sphingolipids and their functional relevance

 

Chapter 9.  Cell Membrane Repair Pathway Involves Sensing of Dynamics of Caveolae and Caspase-1

 

Chapter 10. Angiogenic Response of Endothelial Cells to Fibronectin

 

Chapter 11. Lactosylceramide synthase as a therapeutic target to mitigate multiple human diseases in animal models

 

Chapter 12. Advanced Fret Methodologies: Protein Lipid Selectivity detection and Quantification

 

Chapter 13.  Mechanism of GPCR-directed Autoantibodies in Diseases

 

Chapter 14. Role of Membrane Cholesterol in Leishmanial Infection

 

Chapter 15. How Intact is the Basement Membrane? Role of MMPs

 

Chapter 16. Apoptosis of Breast Cancer Cells: IX. Modulation of Genes for Glycoconjugate Biosynthesis and Targeted Drug Delivery

 

Chapter 17. Altered expression of sialidases in human cancer

 

Chapter 18.  Poly-ADP-ribosylation of  vascular endothelial growth factor and its implications on angiogenesis.

 

Chapter 19. Sphingolipid Binding Domain in the Serotonin1A Receptor

 

Chapter 20. Withanolide-D, carrying the baton of Indian Rasayana herb as a lead candidate of anti-leukemic agent in modern medicine

 

Chapter 21.  Engineered glucose to generate a spectroscopic probe for studying carbohydrate biology

 

Chapter 22. Changes in sialic acid content of jelly coat in pesticide exposed frog eggs and its influence on fertilization

O autorze

Prof. Perumana R. Sudhakaran is currently the Dean of the School of Biological Sciences and Professor of Biochemistry, Central University of Kerala, Kasargod, India. His major area of research is cell extracellular matrix interaction and cell signaling. Prof. Avadesha Surolia is currently the Director of the National Institute of Immunology, New Delhi and a Professor of Molecular Biophysics at the Indian Institute of Science, Bangalore, India. His major areas of research include structure and function of lectins, orientation and dynamics of cell surface carbohydrate receptors, protein folding and quality control in the endoplasmic reticulum.

Blurb

The 2011 international symposium on the “Biochemical Role of Eukaryotic Cell surface Macromolecules” (Trivandrum, India - Jan 2011) covered topics on the analysis of glycome, biophysical approaches to study cell surface molecules, glycoconjugate metabolism and its dysregulation, and molecular mechanisms involved in cell-cell and cell–matrix interaction.  Contributions from this meeting are presented this volume, providing an in-depth analysis of data on cell surface macromolecules in cellular function and their alteration associated with pathological conditions. All contributions are either comprehensive critical reviews or original research papers and cover the most relevant and recent topics related to functional role of cell surface molecules.