Biocatalysis in the Pharmaceutical and Biotechnology Industries

ISBN-13: 9780849337321 / Angielski / Twarda / 2006 / 893 str.

Ramesh Patel; Patel Patel; Ramesh Patel

Opis

Biocatalysis in the Pharmaceutical and Biotechnology Industries presents different classes of enzymes in catalysis of chemical reactions to generate chiral molecules and fine chemicals useful in chemo-enzymatic synthesis of pharmaceuticals and agrochemicals. This book explores developments in the biotechnology of enzymes. It covers the use of oxido-reductases, amine oxidases, and aminotransferases in the synthesis of chiral alcohols, aminoalcohols, amino acids, and amines. It discusses aldolases and decarboxylases in asymmetric synthesis and describes techniques in enzyme immobilization, approaches to screen for biocatalysts, and directed evolution of biocatalysts for improving enantioselectivity and substrate specificity.

Spis treści

Enzymatic/Microbial Preparation of Chiral Epoxides. Preparation of Optically Active Cyanohydrins using Hydroxynitrile Lyases. High-throughput Biocatalysis for Accelerated Drug Discovery and Development. Enhancing the Stability of Industrial Enzymes. Biocatalytic Hydroxlation Reactions. Dehydrogenases in Synthesis of Chiral Pharmaceuticals. Biocatalysis: Applications and Potentials for the Chemical Industry. Biocatalysis using Enzymes and Microorganisms. Vitamins and Related Compounds: Microbial Production. Biocatalysis in the Preparation of Homochiral Pharamaceuticals. Stereochemistry and Evoluation of Aminotransferases. Chemoenzymatic Synthesis of Chiral Intermediates. Overview of Biocatalysis in Ionic Liquids. Preparative Biotransformations. Directed Evolution and Biocatalysis: Enantioselective Production of Amino Carboxylic Acids. Design, Sequences, and Use of Mutant Haloalkane Dehalogenases. Enantioselective Biocatalysis using Lipases and Esterases. Biocatalysis: Reduction of C=N Bonds. Stereospecific Biocatalytic Epoxidation. Cytochrome P450 BM-3: Directed Evolution & Hydroxylation Reactions. Stereoselective Synthesis of Nucleoside Analogues. Microbial Baeyer-Villiger Oxidations. Developing Novel Biocatalysis for Manufacturing Optically Active Compounds. Enzymatic Asymmetric Synthesis by Decarboxylases. Enzymatic Asymmetric C-C Bond Synthesis. Chemoenzymic Synthesis of Glycophosphopeptides. Recent Advances on Bioreductions Mediated by Baker’s Yeast and Other Microorganisms. Biotransformation and Organic Chemistry. Synthesis of Optically Active Pheromones. Microbial Carboxylations in Enantioselective Synthesis. Lipases and Oxynitrilases: Useful Tools in Organic Synthesis. Enzymatic Asymmetric using Aldolases. Enzymatic Racemization and its Application to Synthetic Biotransformations. Amidases and Dehydrogenases in Asymmetric Synthesis. Biocatalysis in Organic Synthesis. Enantiopure Alcohols by Enzymatic Resolution with In-situ Racemization. Engineered Enzyme

O autorze

Patel, Ramesh N.