Bioactive Compounds from Natural Sources: Natural Products as Lead Compounds in Drug Discovery

ISBN-13: 9781439822296 / Angielski / Twarda / 2011 / 648 str.

Tringali, Corrado

Opis

The first edition of Bioactive Compounds from Natural Sources was published in a period of renewed attention to biologically active compounds of natural origin. This trend has continued and intensified-natural products are again under the spotlight, in particular for their possible pharmacological applications. Largely focusing on natural products as lead compounds in drug discovery, Bioactive Compounds from Natural Sources, Second Edition: Natural Products as Lead Compounds in Drug Discovery is actually a completely new volume containing surveys of selected recent advances in an interdisciplinary area covering chemistry of natural products, medicinal chemistry, biochemistry, and other related topics. Written by some of the most reputed scientists in the field, this second edition includes new chapters from authors who contributed to the first edition as well as many chapters compiled by new authors. Introducing the reader to strategies and methods in the search for bioactive natural products, this book covers topics including:

• Natural sources of bioactive compounds such as aquatic cyanobacteria, filamentous fungi, and tropical plants,
• The tremendous potentiality of metabolic engineering of natural products biosynthesis
• The contribution of emerging or developing technologies to the study of bioactive natural compounds, namely computational methods and circular dichroism
• The potential of natural or natural-derived compounds for specific therapeutic applications: treatment of viral diseases, regulation of hypoxia-inducible factor, antimalarials, modulation of angiogenesis, and antitumor and wound-healing activity
• Selected examples of natural product families and related synthetic analogues, namely polyphenols and campthotecins

Compiled for researchers and Ph.D. students working in interdisciplinary fields, this book will also be appreciated by readers without a background in chemistry interested in bioactive natural products, their biological and pharmacological properties, and their possible use as chemopreventive or chemotherapeutic agents. Conversely, the biological and pharmacological data and methods are accessible by chemists.

Spis treści

Strategies and Methods for a Sustainable Search for Bioactive Compounds. Discovery of Potential Anticancer Agents from Aquatic Cyanobacteria, Filamentous Fungi, and Tropical Plants. Metabolic Engineering of Natural Product Biosynthesis. Computational Approaches for the Discovery of Natural Lead Structures. Recent Advances in the Application of Electronic Circular Dichroism for Studies of Bioactive Natural Products. Natural Products as Treatments for and Leads to Active Compounds in Viral Diseases. Natural Products as Inhibitors of Hypoxia-Inducible Factor-1 (HIF-1). From Antitumor or Wound Healing Actions of Natural Products through Angiogenesis. From Natural Polyphenols to Synthetic Antitumor Agents. Resveratrol against Major Pathologies: From Diet Prevention to Possible Alternative Chemotherapies with New Structural Analogues. Drug Discovery from Natural Substances—A Case Study: Camptothecins. Plant Compounds and Derivatives as Inhibitors of Cancer Cell Multidrug Resistance. Recent Advances in the Search of　 Novel Calmodulin Inhibitors from Selected Mexican Plants and Fungi. Neuroprotective Effects of Natural Products from Traditional Chinese Herbs. Drugs for the Neglected Disease Malaria based on Natural Products. Endophytic Microorganisms as a Source of Bioactive Compounds. Biologically Active Natural Products from Australian Marine Organisms.

O autorze

Professor Corrado Tringali obtained his BA in chemistry at the University of Catania, Italy, in 1973. From 1977 to 1985 he was an assistant professor, teaching courses in organic chemistry and physical methods in organic chemistry. In November 1985 he became an associate professor (organic chemistry), and since November 2001 he has been a full professor (teaching courses in organic chemistry, natural products chemistry, and physical methods in organic chemistry). At present, he is coordinator of the international Doctorate of Research in Chemical Science program at the University of Catania (Cycles XXII –XIV).