Bile Acids and Hepatobiliary Diseases - Basic Research and Clinical Application

ISBN-13: 9780792387251 / Angielski / Twarda / 1997 / 331 str.

G. Paumgartner; W. Gerok; A. Stiehl

Opis

Since the last International Bile Acid Meeting in San Diego in 1994, new advances have been made in the understanding of bile acid metabolism and transport. The cytotoxic as well as the therapeutic effects of specific bile acids have been further explored and the beneficial effects of ursodeoxycholic acid in various chronic cholestatic conditions have been substantiated. Much basic and clinical research has been conducted to unravel the underlying mechanisms of action.
This volume, the proceedings of Falk Symposium No. 93 (XIV International Bile Acid Meeting), held in Freiburg-im-Breisgau, Germany, October 22-24, 1996, is dedicated to both basic and clinical aspects of bile acid research related to the role of bile acids in hepatobiliary diseases.

Spis treści

Adolf-Windaus-Award 1996; W. Gerok. Adolf-Windaus-Prize Lecture: Bile Acid Transport Systems as Pharmaceutical Targets; W. Kramer. I: Bile Acid Biosynthesis and Metabolism. 1. Determinants of Biliary Bile Acid Composition in Mammals: Influence of Age and Gender; M. Gavrilkina, et al. 2. Identification of a Unique Inborn Error in Bile Acid Conjugation Involving a Deficiency in Amidation; K.D.R. Setchell, et al. 3. Regulation of Sterol 27-Hydroxylase and Its Role in the Regulation of `acidic' Pathway of Bile Acid Synthesis; Z.R. Vlahcevic, et al. 4. Sterol 12alpha-hydroxylase: a Key Cytochrome P-450 in Bile Acid Synthesis. Cloning and Expression of the Rabbit Enzyme; G. Eggertsen, et al. 5. Stereochemistry of Peroxisomal Side-Chain Degradation in Bile-Salt Biosynthesis; W. Dieminger, et al. 6. Does Cisapride Overcome the Effects of Octreotide on Intestinal Transit, Thereby Reducing the Proportion of Deoxycholic Acid in Bile and Serum? M.J. Vesey, et al. II: Hepatic Bile Acid Transport. 7. Regulation of Bile Acid Carrier Expression in Normal and Diseased Liver; P.J. Meier. 8. Regulation of the Organic Anion Transporting Polypeptide of Human Liver; G.A. Kullak-Ublick, et al. 9. Regulation of Bile Acid Transporters in Experimental Cholestasis; C. Gartung, J.L. Boyer. 10. Regulation of Hepatocyte Bile Salt Transporters by Endotoxin and Cytokines; R.M. Green, J.L. Gollan. 11. ATP-Binding Cassette Proteins and the Molecular Basis of Liver Cell Membrane Transport; N. Lomri, et al. 12. ATP-Dependent Transport of Dianionic Bile Salts by the Canalicular Isoform of the Multidrug Resistance Protein (MRP2/cMRP/cMOAT); D. Keppler, et al. 13. Cloning and Characterization of cMOAT, a Transporter for Divalent Anionic Bile Salts; C.C. Paulusma, et al. 14. Stimulation of Bile Acid Secretion by Tauroursodeoxycholate and Cell Swelling Involves Mitogen-Activated Protein Kinase; D. Häussinger, et al. III: Intestinal Bile Acid Transport. 15. The Molecular Genetics of Ileal Bile Acid Transport; P.A. Dawson, P. Oelkers. 16. Properties and Specificity of the Rabbit Ileal Na⁺/Bile Acid Cotransport System; W. Kramer, et al. 17. Regulation of the Sodium-Dependent Ileal Bile Acid Transporter in the Rat; R.T. Stravitz, et al. 18. Effect of Cholestasis on Ileal and Jejunal Absorption of Bile Acids in Rat; P. Sauer, et al. 19. Cloning and Characterization of a Regulon Involved in Bile Acid Transport and 7-Dehydroxylation in an Intestinal Eubacterium Species; D.H. Mallonee, P.B. Hylemon. IV: Biological Actions of Bile Acids. 20. Effects of Bile Acids on Bile Secretion; J.L. Boyer. 21. Modulation of Hepatocellular Signaling by Bile Acids; U. Beuers, et al. 22. Ursodeoxycholate Activates Ca²⁺-dependent Cl^- currents in a Human Biliary Cell Line; R. Roman, et al. 23. Bile Salt Stimulation of Biliary Phospholipid Secretion; J.M. Crawford. 24. Organic Anions Do Not Impair Bile Salt Micellization in In Vitro Model Bile Systems: Implications for the Mechanism of Organic Anion-Induced Inhibition of Biliary Lipid Secretion In Vivo; H.J. Verkade, et al. 25. Antioxidant Properties of Bile Acids Evaluated with Enhanced Chemiluminescent Assay: A Possible Physiological Role; A. Roda, et al. 26. Bile Salt Induces Alterations in Bilayer Permeability: Insights Into Cytoprotection and Cytotoxicity; A. Albalak, et al. 27. Effector Proteases in Bile Salt-Induced Hepatocyte Apoptosis; L.R. Roberts, et al. 28. Borderline Pathology in mdr2(-l-) Rescue Mice: A New Model to Study Non-Suppurative Cholangitis; M. de Vree, et al. 29. Effects of Deoxycholic Acid on Cholesterol and Bile Acid Metabolism in Human Liver; C. Einarsson, et al. 30. Bile Acids Modulate the Interferon Signalling Pathway; P. Podevin, et al. 31. Obstructive Cholestasis Inhibits the Rate of Cholesterol 7&agr;-Hydroxylation in Humans In Vivo; M. Bertolotti, et al. V: Bile Acids in Therapy. 32. Multi-Drug Treatment for Primary Biliary Cirrhosis: Is More Better?; B.J.F. van Hoogstraten, et al. 33. Ursodeoxycholic Acid in Combination with Prednisolone or Budenoside in the Therapy of Primary Biliary Cirrhosis; U. Leuschner, et al. 34. Bile Acid Synthesis, Metabolism and Secretion in Primary Biliary Cirrhosis Before and After Steroid and Colchicine Treatment; E. Roda, et al. 35. Medical Treatment of Primary Sclerosing Cholangitis: On the Role of Ursodeoxycholic Acid; A. Stiehl, et al. 36. Ursodeoxycholic Acid in the Treatment of Cholestasis of Pregnancy; J. Palma, et al. 37. Clinical Outcome of Long-Term Treatment of Ursodeoxycholic Acid in Patients with Cystic Fibrosis-Associated Liver Disease; C. Colombo, et al.