Autophagy in Immune Response: Impact on Cancer Immunotherapy

ISBN-13: 9780128196090 / Angielski / Twarda / 2020 / 400 str.

Salem Chouaib

Recenzje

"series on the Tumor Microenvironment (edited by Alexander Birbrair, published by Springer), which has published several volumes already, but none dedicated to autophagy. In general, this book has an ambitious goal of summarizing the current state of knowledge regarding autophagy's role in anti-tumor immune responses, but unfortunately, there does not seem to be a lot known, which results in a number of the chapters appearing fairly repetitive and redundant. Some other chapters are able to provide interesting reviews on topics related to tumor immunology but with a tenuous connection to autophagy, such as the chapter on lectins, while some others thoroughly discuss interesting mechanisms of autophagy regulation but with only brief references to immune regulation, such as the chapter on Yin-Yang 1. Accordingly, this book could have better achieved its goals by consolidating some of the chapters (such as eight or nine chapters instead of 11) for ease of reading, but nevertheless represents a very useful resource for researchers interested in this emerging field. There are no previous editions to this work, but as more is discovered, a newer edition would be extremely beneficial." --Doody

Spis treści

1. Signaling pathways that control autophagy2. Autophagosome biogenesis3. Autophagy in T and B cell homeostasis: Recycling for sustainable growth4. Autophagy is involved in quality/quantity control of organelles and their homeostasis5. Role of autophagy in immune regulation6. Autophagy in natural and therapy-driven anticancer immunosurveillance7. Autophagy and resistance to cell-mediated cytotoxicity8. Autophagy and metabolism9. Autophagy in connecting immunity and metabolism10. Autophagy in tumor cell migration and invasion, tumor stem cell maintenance and therapy resistance11. Autophagy during Early Virus-Host Cell Interactions12. Diverse roles for autophagy in impeding and promoting tumorigenesis13. The autophagic network and cancer14. Targeting Autophagy in the Tumor Microenvironment15. Autophagy and microbiota16. Regulation of autophagy and mitochondrial dynamics17. Autophagy proteins in cell defenses and role in bacteria-macrophage interaction18. Autophagy, a key player in leukemogenesis and a therapeutic target in hematopoietic malignancies19. Autophagy in Cancer and Cancer Therapy20. Autophagy in the Tumor or in the Host: Which Plays a Greater Supportive Role?21. Autophagy and cancer therapy22. Therapeutic potential of autophagy modulation in the clinic23. Rationale and current approaches for developing autophagy inducers in medicine24. Autophagy and metabolism

O autorze

For more than 20 years Dr. Salem Chouaib has focused his research on killer cells and cell death; he first was interested in the differentiation of cytotoxic T lymphocytes, then in the molecular basis of tumor resistance to the cytotoxic action of TNF. During the past ten years, Dr. Chouaib's research was devoted to the influence of tumor microenvironment on stroma reactivity and tumor heterogeneity. His team was the first to establish the link between hypoxic stress and the acquisition of tumor resistance to cell-mediated cytotoxicity; they found in fact that autophagy was a potential pathway linking hypoxia to the acquisition of resistant phenotype including stemness and epithelial to mesenchymal transition. Dr. Chouaib has a wide knowledge of the killing mechanisms and the tumor resistance as well.