Analytical Studies of Croscarmellose Sodium

ISBN-13: 9786205490075 / Angielski / Miękka / 68 str.

Kuldeep Joshi; Bharatkumar Prajapati

Opis

Croscarmellose sodium (CCS) is carboxymethylated and cross-linked polymer of cellulose. In the synthesis, pure cellulose extracted from wood or cotton fiber is steeped in sodium hydroxide solution to form alkali cellulose. Carboxymethyl cellulose is obtained by reacting the alkali cellulose with sodium monochloroacetate. At the end of the substitution reaction, the sodium hydroxide is used up and the remaining sodium monochloroacetate gradually hydrolyzes to form glycolic acid. The glycolic acid catalyzes cross-linking to produce CCS. CCS is finally obtained by extracting with aqueous alcohol and any trace sodium glycolate and sodium chloride are removed. The objective of the study was to analyze parameters such as weight, density, pH, conductivity, particle size, moisture content, organic impurities, solubility, bulk density etc. Above all tests are complies with the regulatory specification limitation.

O autorze

Dr. Kuldeep Joshi is an Associate Professor of Chemistry currently working in the Department of Chemistry, Indus University, Ahmedabad, Gujarat, India. He has almost 15 years of teaching and research experience in the area of Analytical Chemistry. He has published around 25 research articles in reputed peer-reviewed journals.