Alternatives to Antibiotics: Recent Trends and Future Prospects

ISBN-13: 9789811918537 / Angielski / Twarda / 2022

Saha, Tilak

Opis

This book discusses prospective alternative approaches to fight bacterial infections to minimize the indiscriminate use of conventional antibiotics. It offers the current knowledge on research and development of alternative antibacterial agents such as probiotics, nanobiotics etc. while it also discusses newly emerging trends such as phage therapy, antibody therapy etc. The book highlights on the phytochemicals with potent antibacterial activities as alternatives to conventional antibiotics. Chemical modification to develop next generation antibiotics with enhanced efficacy has also been included. Such modifications are reported to overcome the inherent resistance of the parent antibiotics. Phage therapy and targeted antibodies are considered as potential alternative approaches to treat bacterial ailments and represent areas of cutting-edge research and have therefore been discussed with sufficient care. Mainly, the book highlights various approaches other than conventional antibiotics in treating bacterial infections. The scientific advancements in these areas will strengthen the ‘One Health’ approach benefiting human beings, animals and environment as well. This book is a comprehensive resource to cater researchers, biological scientists, herbalists and clinical practitioners with up-to-date information on antibacterials other than antibiotics.

Spis treści

Chapter 1. Quest for alternatives to antibiotics - an urgent need of the 21st century.- Chapter 2. Phytochemicals as antibacterial agents: current status and future perspective.- Chapter 3. Quorum quenching enzymes: a potent alternative to conventional antibiotics.- Chapter 4. Antibodies as antibacterial molecules: the new era of antibody-mediated immunity.- Chapter 5. Phage therapy: genomics to applications and future prospects.- Chapter 6. Alternatives to antibiotics in animal farming.- Chapter 7. Metal catalysed synthesis of b–lactam antibiotics.- Chapter 8. Upgrading the antibiotic arsenal against gram-positive bacteria: chemical modifications of vancomycin.- Chapter 9. Heterocyclic scaffolds in novel synthetic antibacterial agents.- Chapter 10. Antibacterial metal-organic frameworks.- Chapter 11. Cationic amphiphilic molecules as bactericidal agents.- Chapter 12. Polymeric nanoparticles and nanocomposites as antibacterial agents.- Chapter 13. Metallic nanoparticles and their composites as alternative antibacterial therapeutics.- Chapter 14. Carbon nanoparticles as the next generation antimicrobial agents.- Chapter 15. Dendrimeric entities as chemical alternatives towards antimicrobial therapy.- Chapter 16. Ionic liquids, ionic liquid nanoparticles and nanocomposites-the future antibiotics.- Chapter 17. Prebiotic immunomodulators to enhance mucosal immunity and to reduce mass use of antibiotics.- Chapter 18. Use of probiotics, prebiotics and synbiotics as an alternative to antibiotics.- Chapter 19. The implication of antimicrobial peptides against bacteria and their clinical aspects.- Chapter 20. development of probiotics for helocibacter pylori infection management.- Chapter 21. Implications of probiotics in management of bacterial infections.- Chapter 22. Nano carriers for the molecular targeting of pathogenic bacteria.

O autorze

Dr. Tilak Saha is an Assistant Professor (Senior) in the Department of Zoology, University of North Bengal, Siliguri, West Bengal, India. He completed Post-Graduation in Zoology and Ph.D. in Biotechnology from the University of North Bengal. His main areas of research are medical microbiology, Immune system and host microbe interaction. He has published research papers in scientific journals such as Scientific Reports, International Journal of Systemic and Evolutionary Microbiology (Microbiology Society), New Journal of Chemistry, ACS Physical Chemistry Au, Current Science etc. He also has edited a book entitled “Microbes, Environment and Human Welfare” ISBN- 978-1-53617-945-3, NOVA Science Publisher, USA.

 Dr. Manab Deb Adhikari completed Ph.D. in Biotechnology from IIT-Guwahati, India. He worked as Research Professor in the Department of Chemical and Biological Engineering, Korea University, Seoul, South Korea during 2014-18. He is currently working as Assistant Professor at the Department of Biotechnology, University of North Bengal, Siliguri, India. His current research interest includes Nanobiotechnology, Antibacterials, Drug Delivery, Antimicrobial Peptides, Probiotics and Prebiotics. He has published research works in Chemical Communications, Advanced Healthcare Materials, Biomacromolecules, Journal of Materials Chemistry B, Inorganic Chemistry, etc. He is a permanent member of Society for Biotechnologists (INDIA) and Association of Microbiologists of India (AMI).

 Dr. Bipransh Kumar Tiwary is Assistant Professor and Head in the Department of Microbiology, North Bengal St. Xavier’s College, Rajganj, Jalpaiguri, West Bengal, India. He received M.Sc. in Microbiology and Ph.D. in Biotechnology from University of North Bengal, Siliguri, India. He is a lifetime member of Association of Microbiologists of India (AMI). His areas of research are Medical Microbiology, CADD, Antimicrobials and Quorum Sensing Inhibitors. He has published research works in Plos one, RSC Advances, BMC complementary and Alternative Medicine and Letters in Applied Microbiology. He has edited a book entitled “Microbes, Environment and Human Welfare” ISBN-9781536179453, NOVA Science Publisher, USA.