Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications

ISBN-13: 9789048158812 / Angielski / Miękka / 2010 / 206 str.

Bengt Samuelsson; Rodolfo Paoletti; Giancarlo C. Folco

Opis

This volume is the proceedings of the 11th International Conference on Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications, held in Florence, Italy, on June 4-8, 2000, which continues the tradition of covering both basic and clinical aspects of prostaglandin and leukotriene research.

At this meeting particular emphasis was given to the potential application of the novel COX-2 inhibitors, the genetics of asthma relating to the production of leukotrienes, and novel cellular networks for the production of leukotrienes and lipoxins.

Traditionally, as has been done in past meetings of this series, a considerable amount of new material was presented and discussed this year, with particular attention given to the newest clinical data.

Spis treści

Preface. List of Contributors. I: Lipoxygenases and Leukotriene Biosynthesis. 1. Phosphorylation and Activation of 5-Lipoxygenase by P38 Kinase-Activated MAPKAP Kinases; O. Werz, et al. 2. 5-Lipoxygenase and the Nucleus: Where, When, How, and Why?; M. Peters-Golden, T.G. Brock. 3. Calcium Binding Site of 5-Lipoxygenase; T. Hammarberg, et al. 4. Regulation of Cellular 50Lipoxygenase Activity by Glutathione Peroxidases; D. Schumann, et al. 5. Novel Aspects Related to Biosynthesis and Biological Actions of Hepoxilins: Interrelationship with Phospholipid Hydro-Peroxide Glutathione Peroxidase (PHGPx); P. Shankaranarayanan, et al. 6. Transcriptional Regulation of the Human Leukotriene C4 Synthase Promoter; J.-L. Zhao, et al. 7. Localization and Translocation of Enzymes Involved in Leukotriene Biosynthesis; Y. Ide, et al. II: Cyclooxygenases and Prostaglandin Biosynthesis. 8. Regulation of COX-2 Expression in Fibroblasts, Osteoblasts, Mast Cells, and Macrophages; H.R. Herschman, et al. 9. Antimicroinflammatory Lipid Signals from Vascular Cyclooxygenase-2: A Novel Mechanism for NSAID and N-3 PUFA Therapeutic Actions; C.N. Serhan, et al. 10. Substrate Interactions in the Cyclooxygenase-1 Active Site; E.D. Thuresson, et al. 11. Mutation of the Human Prostacyclin Synthase Gene; T. Nakayama, et al. 12. Structure and Function of Two Distinct Types of Prostaglandin D Synthase; Y. Urade, O. Hayaishi. 13. Roles of Prostaglandin F Synthase; K. Watanabe, et al. 14. Differential Effects of Nitric Oxide on Cyclooxygenase 1 and 2 Activities in Cultured Cells; S.-I. Murota, et al. III: Phospholipase A2. 15. On the Functional Diversity of Secreted Phospholipases A2: Cloning of Novel Mammalian and HIV-1 Antiviral Properties; G. Lambeau, et al. 16. Regulation of Cytosolic Phospholipase A2 by Phosphorylation; M.H. Gelb, et al. IV: Cytochrome P450 Archidonate Metabolites. 17. Synthesis and Function of 20-Hydroxyeicosatetraenoic Acid in the Kidney; M.L. Schwartzman, et al. V: Receptors. 18. Altered Bronchodilation and Pulmonary Inflammation in Prostanoid EP2 Receptor Knockout Mice; F. Nantel, et al. 19. Induction of Prostaglandin I2 Receptor in Murine Osteoblastic Cell; K. Yamamoto, et al. 20. BLT2, a Second Leukotriene B4 Receptor; T. Yokomizo, et al. 21. Upregulation of Cysteinyl-Leukotriene 1 Receptor Expression by Interleukin-5 in Human Leukocytes; M. Rola-Pleszczynski, et al. 22. Physiological and Pathophysiological Roles of Prostanoids; Lessons from Receptor-Knockout Mice for Clinical Applications; S. Narumiya. 23. Multiple G-Protein Coupling of Chimeric Prostacyclin/Prostaglandin D2 Receptors; H. Wise, K.B.S. Chow. VI: Eicosanoids and Neuroscience. 24. An Unusual Nicotinic Acetylcholine Receptor Activates the 8-Lipoxygenase Pathway in Aplysia Neurons; S.J. Feinmark, et al. VII: Cardiovascular System. 25. Neutrophil-Endothelial Cell Interaction: A Multidirectional Cross-Talk in Leukotriene Generation; G.C.