Advances in Chromatography, Volume 49

ISBN-13: 9780367383022 / Angielski / Miękka / 2019 / 461 str.

Eli Grushka; Nelu Grinberg

Opis

This venerable series has reported on the latest state-of-the-art developments in the field for the past four decades. Volume 49 continues the tradition of compiling the work of expert contributors who present cutting-edge reviews of methods and applications in chromatography. Highlights in this edition include: the hyphenation of liquid chromatography with mass spectrometry in order to determine oligonucleotide adducts as markers for cancer; glycoproteomics and the glycosylation of proteins, addressing biomarkers in different types of diseases; and chiral separation, an important area particularly in the pharmaceutical industry; and ion-pairing chromatography and analyte retention.

Spis treści

Retention Mechanism for Ion-Pair Chromatography with Chaotropic Reagents: From Ion-Pair Chromatography toward a Unified Salt Chromatography. Mechanistic Aspects of Chiral Recognition on Protein-Based Stationary Phases. Mechanistic Aspects and Applications of Chiral Ligand-Exchange Chromatography. Glycosylation Analysis of Proteins, Proteoglycans, and Glycolipids Using Capillary Electrophoresis and Mass Spectrometry. Oligonucleotide Adducts as Biomarkers for DNA Damages: Analysis by Mass Spectrometry Coupled to Separation Methods. Quantitative In Silico Analysis of the Specificity of Graphitized (Graphitic) Carbons. Application of Column-Switching Methods in HPLC for Evaluating Pharmacokinetic Parameters. Chromatographic Procedures in a Regulated Environment. The Use of Novel Materials as Solid-Phase Extractors for Chromatographic Analysis. Thin-Layer and High-Performance Thin Layer Chromatographic Analysis of Biological Samples. Index.

O autorze

Eli Grushka is currently with Hebrew University of Israel, Jerusalem. Nelu Grinberg is with Boehringer-Ingelheim Pharmaceuticals of Ridgefield, Connecticut.