Adult celiac disease and associated autoimmune diseases

ISBN-13: 9786204449012 / Angielski / Miękka / 2022 / 52 str.

Fatma Rekik; Faten Frikha; Zouhir Bahloul

Opis

Celiac disease (CD) is an autoimmune inflammatory enteropathy, caused by one of the protein fractions of gluten (food antigen), gliadin (a protein contained in wheat, rye and barley) and which occurs in genetically predisposed subjects [1,2,3]. Its pathogenesis results from the interaction between genetic, immunological and environmental factors which, through the intervention of the human leukocyte antigen (HLA) class II genes (encoding the HLA-DQ2 molecule, and those encoding the HLA-DQ8 molecule) induce an immune response in the intestinal mucosa leading to villous atrophy resulting in malabsorption, and the presence of specific antibodies in the serum of patients, which has changed the epidemiological view of celiac disease. The association with other autoimmune diseases (AID) is frequent, which imposes their systematic research. The aim of our work was to evaluate the prevalence of autoimmune diseases during celiac disease and to analyze their epidemiological, clinical, and immunological profile.

O autorze

Dr. Fatma Rekik is an Associate Professor of Internal Medicine in the Department of Internal Medicine at the University of Sfax School of Medicine, Tunisia. She received her PhD in Internal Medicine in 2015 and is the author of over 60 articles in scientific journals.